运动干预铁死亡进程改善非酒精性脂肪肝的机制研究

【中图分类号】G804 【文献标识码】A 【文章编号】2095-2813（2025）21-0005-04

Research on Mechanism of Exercise Intervention in Iron Death - Process to Improve Non-AlcoholicFatty Liver Disease

ZHANG Xinyu

InnerMongoliaNormal UniversityInstituteofPhysicalEducation，Hohhot，InnerongoliaAutonomousRegion， China

[Abstract]Physical exercise is regarded asan efectivenon-pharmaceutical means tocombat metabolicdiseases.Inrecent years，aerobic exercisehas shown remarkable results in the treatment of non-alcoholic fatt liver disease，which can significantly reverse thedegenerationoflivercelsinfatyliverand alleviate thecondition.Iron dependent programmed cell death isanovelformofcelldeath thatis dependentoniron.Researcheshaveshown thatintheliverof patients withnon-alcoholicfattyliverdiseasetheexpressionofGPX4proteinisdecreasedandirondeathisexacerbated.Exercise can inhibit iron death and improve non-alcoholic faty liver disease by down-regulating lipid peroxidation，upregulating the System Xc-. -GSH-GPX4 pathway and regulating iron metabolism.

[Keywords] Exercise; Iron death;NAFLD;GPX4

肝脏是铁稳态的关键场所，也是机体主要的代谢器官。（剩余7964字）