心脏磁共振参数对肥厚型心肌病心肌纤维化的诊断价值

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[Abstract]Objective： To investigate the diagnostic value of cardiac magnetic resonance （CMR） parameters in myocardial fibrosis of hypertrophic cardiomyopathy （HCM）.Method：This prospective study enrolled 8O patients with HCM complicated by myocardial fibrosis who underwent CMR examinations at Xinyu People's Hospital from February 2O22 to February 2O25 as the observation group. Concurently，80 healthy individuals undergoing physical examinations at the same hospital during the same period were designated as the control group.The CMR parameters of the two groups were compared，the diagnostic value of CMR parameters for myocardial fibrosis in HCM was evaluated using ROC curves.Result： There were no significant differences in gender，age and body mass index between the two groups （P>0.05） ; the heart rate，diastolic blood pressure and systolic blood pressure in the observation group were higher than those in the control group 'P<0.05 ）.Among the CMR parameters of the observation group，the level of left ventricular ejection fraction （LVEF） was lower than that in the control group 0 P <0.05），the levelsof left ventricular wall thickness（LVWT），left ventricular end systolic volume （LVESV），left ventricular mass index （LVMI），Native Γ1 and extracellular volum （ECV） were higher than those in the control group （ P <0.05）. The area under the curve （AUC）of LVEF，Native Tand ECV in CMR parameters for the diagnosis of myocardial fibrosis inHCMwas0.7O5，0.609andO.784，respectively.Conclusion：ThelevelsofLVWT，LVESV， LVEF， Native T1 and ECV in CMR parameters of HCM complicated by myocardial fibrosis patients will change. CMR parameters such as LVEF，Native TandECVcanbeused asan auxiliarydiagnostic toolfor HCMfibrosis and have certain diagnostic value.

[Keywords] Hypertrophic cardiomyopathyMyocardial fibrosisCardiac magnetic resonanceDiagnostic value

First-author'saddress：Image Center，XinyuPeople'sHospital，Xinyu338ooo，China doi：10.3969/j.issn.1674-4985.2025.32.035

肥厚型心肌病（hypertrophic cardiomyopathy，HCM）是一种以左心室壁异常肥厚为主要特征的遗传性心脏疾病，而心肌纤维化是HCM进展中的核心病理改变，表现为胶原纤维在心肌间质过度沉积，形成替代性纤维化或弥漫性间质纤维化，进而导致心肌僵硬度增加、电传导异常，最终引发心力衰竭、恶性心律失常甚至猝死[1-3]。（剩余6168字）