COPD患者血清PCT、IL-6水平与肺功能指标的相关性分析

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[Abstract]Objective：To explore thecorelation between the levels of serum procalcitonin （PCT）， IL-6and pulmonary function indicators in patients with COPD.Method：According to the GOLD clasification，3O patients with COPD at various stages who were admited to Xiamen Haicang Hospital from October 2O22 to October 2024 were retrospectively selected and divided into four groups， the mild group [percentage of FEV1 to the predicted value （FEV % pred） ⩾ 80%]， the moderate group （FEV 1% pred between 50% and less than 80% ）， the severe group （FEV 1% predbetween 30% and less than 50% ），and the extremely severe group （FEV % pred <30% ）.Thebaseline dataandPCT，IL-6of the four groups were compared.Pearson corelation analysis was used to explore the correlatin between serum PCTand IL-6 levelsand lung function indexes （FEV%pred，FEVi/FVC）.Result： The comparisonof diseaseduration，ageandtheproportionofsmokersamong thefour groupsshowedstatisticallysignificantdifferences （ P <0.05），among which the proportion of disease duration，ageand thenumber of smokers inthe extremely severe group were the highest. FEV % predandFEV 1′ /FVC decreased with the increase of GOLD severity， there was a statisticallysignificant difference among the four groups （ P <0.05）.The levelsof PCTand IL-6 both increased with the severity of GOLD classification，there was a statistically significant difference among the four groups （ P <0.05）. Pearson analysis showed that PCT was negatively correlated with FEV1%pred （ r= -0.758，P<0.001），and IL-6 wasnegativelycorrelatedwithFEV，/FVC（ r=. -0.693， P<0.001 ）.Conclusion：Serum PCT in COPD patientswas negatively correlated with FEV1%pred，and IL-6 was negatively correlated with FEV1/FVC.

[Keywords] COPD PCT IL-6 Lung function

First-author'saddress：Shantou University MedicalCollege，Shantou 515o63，China

doi：10.3969/j.issn.1674-4985.2025.32.033

COPD是一种常见的呼吸系统慢性疾病，主要表现为持续性的呼吸道炎症和气流受限，通常与长期吸烟或空气污染等环境因素密切相关[]。（剩余6350字）