普萘洛尔与凝血酶+奥曲肽治疗肝硬化合并上消化道出血的效果

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[Abstract] Objective：To explore the effects of Thrombin + Octreotide hemostasis regimen assisted with Propranolol on hemodynamic parameters，FIB and cholinesterase （ChE） in patients with cirrhosis and upper gastrointestinal bleeding.Method：A total of 8O patients with cirrhosis and upper gastrointestinal bleeding in Red Star People's Hospital of Jinggangshan General Hospital were retrospectively enrolled from January 2020 to December 2O23.According to different treatment methods，they were divided into control group （35 cases，treated with Octreotide + Thrombin） and observation group （45 cases，treated with Propranolol based on the control group）. Both group were treated for3days.The total effctive rate of treatment，clinical indexes，hemodynamic parameters， FIB，ChE andadverse reactions werecompared betweenthe two groups.Result：The total effectiverateof treatment in observation group was higher than that in control group （ 100% vs 91.43% ， P <0.05）. The blood loss in observation group was lessthan that in control group，hemostasis time was earlier than thatin thecontrol group and length of hospital stay was shorter than that in control group （ P <0.05）.After treatment，blood flowof portal and splenicveins in observation group were less than those in control group，diameters of portal and splenic veins were smaler than those in control group （ P <0.05）.After treatment，levels of FIBand ChE in observation group were higher than those in control group （ P <0.05）.There was no significant difference in the incidence of adverse reactions between the two groups （ P >0.05）. Conclusion： Thrombin + Octreotide hemostasis assisted with Propranolol can improve clinical symptoms，promote hemodynamic stability，improve coagulation function and liver synthesis function inpatients with cirrhosis and upper gastrointestinal bleeding，which has significant curative effect.

肝硬化可由酒精、病毒及血吸虫病等因素导致，是一种由于肝脏代偿性作用异常引起的门静脉高压、肝功能障碍等症状的慢性肝病[1-2]。（剩余5266字）