无创高频振荡通气联合枸橡酸咖啡因对NRDS 患儿动脉血气指标及炎症指标的影响

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Effect of Noninvasive High-frequency Oscillatory Ventilation Combined with Caffeine Citrate on ArterialBlood Gas Indexesand Inflammatory Indexes in Childrenwith NRDS/CHENJiafang.//Medical Innovation ofChina，2025，22（25）：068-071

[Abstract] Objective：To investigate the effects of noninvasive high-frequency oscillatory ventilation （nHFOV）combined with Caffeine Citrateonarterialblood gas indexesand inflammatory indexes inchildren with neonatalrespiratorydistress syndrome （NRDS）.Method： A total of 88children with NRDSadmitted to theAffilited Hospital of Putian University from May 2O22 to March 2O24 wereselected and divided into thecontrol groupand the study group according to the random number table method，with 44 cases in each group.Thecontrol group was treated with nHFOV， whilethe study group was treated with nHFOV combined with Cafeine Citrate.The therapeutic effcts，rterial bloodgas indexes，inflammatoryindexes，ventilatortreatmenttime，totalhospital stayand incidence of complications were compared between the two groups.Result： The total treatment eficiency of the study group was higher than that of the control group （ P <0.05）. After 5 days of treatment， the SaO2 and Pa02 of the study group were higher than those of the control group， the PaCO2 ，CRP， TNF- α and procalcitonin （PCT） of the study group were lower than those of the control group （ P <0.05）. The ventilator treatment time and total hospital stay of the study group were shorter than those of the control group （ P <0.05）.There was no statistically significant difference in the comparison of complications between the two groups P>0.05 ）. Conclusion： Children with NRDS are better treated with nHFOV combined with Cafeine Citrate，which can improve arterial blood gas indexes，reduce inflammatory response， and shorten ventilator use and hospital stay.

[Keywords]Neonatal respiratory distress syndromeNoninvasive high-frequency oscillatory ventilation Caffeine Citrate Arterial blood gas indexesInflammatory indexes

First-author'saddress：DepartmentofNeonatology，theAfiliated HospitalofPutian University， Putian 351100， China doi： 10.3969/j.issn.1674-4985.2025.25.016

新生儿呼吸窘迫综合征（neonatal respiratorydistresssyndrome，NRDS）作为新生儿常见疾病，其好发于早产儿，多因肺表面活性物质缺乏引起，会导致呼吸困难、皮肤青紫等，严重会引起呼吸衰竭，威胁患儿生命安全[1-2]。（剩余5834字）