UGT在癌症进展及耐药中的作用

[Abstract]The uridine dphosphate-glucuronosyltransferase （UGT） family plays a key metabolic and detoxification role in organisms.It improves the water solubility of the compound and promotes its excretion by transfering glucuronic acid groups to form glucuronate.UGT is involved in physiological processes such as drug metabolism，toxin clearance，and hormone metabolism.Incancer research， UGT may afect the efficacy of treatment byremoving carcinogens andregulating drug metabolism.This review highlights theroleof UGTin cancer progression and drug resistance mechanisms，and provides relevant inhibitors and regulators to provide a reference for delaying cancer progression.

[KeyWords]Uridine dphosphate-glucuronosyltransferaseGlucuronic acid InhibitorsRegulators Cancer researchMechanisms of resistance

First-author's address：Medical Oncology of Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine， Suzhou 215oo9， China doi： 10.3969/j.issn.1674-4985.2025.22.040

1UGT在癌症中的基因突变

尿苷二磷酸-葡萄糖醛酸基转移酶（uridinedphosphate-glucuronosyltransferase，UGT）是一种酶，它在生物体内起着重要的代谢和解毒作用。（剩余12748字）