凝血-纤溶标志物、炎症指标与血液透析认知障碍的相关性研究

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[Abstract] Objective： To study the correlation between coagulation-fibrinolysis markers，inflammatory indicators and cognitive impairment in hemodialysis.Method：Thedataof98 patients who underwent maintenance hemodialysis in Yichun People's Hospitalfrom June2O22 toJune 2024 werecolected.Accordingto the scoresof the mini-mental state examination （MMSE），the patients were divided into the cognitive impairment group （ n =39）and the cognitive normal group （n=59 ）.The relationship between the levels of coagulation-fibrinolysis markers （FIB，PT，D-D） and inflammatory factors （TNF- ∝ IL-1β ， IL-6） and cognitive function were analyzed. The predictive ability of these biomarkers forcognitive impairment was evaluated byusing the ROC curve.Result： The levels of FIB，PT， D-D， TNF- α，⌊⌊-1⌋β and IL-6 in the cognitive impairment group were all higher than those in the cognitive normal group （ P <0.05）.Pearson correlation coefficient analysis showed that the MMSE score was negatively correlated with FIB， PT， D-D， TNF- α ，IL- 1β ，and IL-6 （ P<0.05 . The ROC curve showed that FIB，PT， D-D， TNF- ∝ ， IL-1 β ，and IL-6 had good value in predicting cognitive dysfunction （P<0.05 ）.Conclusion： Coagulationfibrinolysis markers and inflammatory indicators have significant correlations with cognitive impairment in hemodialysis and have good predictive value.

[Keywords] Coagulation-fibrinolysis markersInflammatory factorsMaintenance hemodialysis Cognitive impairment

First-author's address：Department ofLaboratory Medicine，Yichun People's Hospital，Yichun 336000， China

doi：10.3969/j.issn.1674-4985.2025.22.030

终末期肾病是全球性的公共卫生问题，其患病率、死亡率及医疗成本不断上升]。（剩余7004字）