紫杉醇+卡铂化疗方案联合三维适形调强放疗治疗非小细胞肺癌的效果及不良反应分析

打开文本图片集

[Abstract] Objective： To analyze the effect and adverse reactions of Paclitaxel + Carboplatin chemotherapy regimencombined with three-dimensional conformal intensity modulated radiation therapy in the treatment of patients with non-smallcellung cancer.Method：A total of 2OO patients with non-small cell lung cancer who wereadmited tothe DepartmentofOncologyand Departmentof Radiotherapyof Liaocheng People'sHospital from January 2O21 to December 2O23 were retrospectively selected.The patients were divided into the control group （ n =100，treated withthree-dimensionalconformal intensity modulatedradiation therapy）and the experimental group （ n=100 ，treatedwithPaclitaxel + Carboplatin chemotherapyregimencombined with three-dimensional conformal intensity modulated radiationtherapy）according todiferenttreatment methods.Thedisease control efect，the levels of tumor markers，vascular endothelial growth factor，matrix metaloproteinase-9，basic fibroblast growth factorand the incidence of adverse reactions in the two groups were statistically analyzed.Result： The objective response rate of the experimental group was 37.00 % （37/100），and the disease control rate was 75.00% （75/10O），which were significantly higher than 12.00% （12/100） and 61.00% （61/100） of the control group （ P <0.05）. After treatment， thelevels of tumor markers，vascular endothelial growth factor，matrix metalloproteinase -9 andbasic fibroblast growth factor in the experimental group were significantly better than those in the control group （ P <0.05）. There was no statistically significant diffrence in the incidence rate of adverse reactions between the two groups （ P- 0.05）.

Conclusion： The treatment of patients with non-small cell lung cancer with Paclitaxel + Carboplatin chemotherapy regimen combined with three-dimensionalconformal intensity modulated radiation therapy hasa good effect and does not increase adverse reactions.

[KeyWords] Paclitaxel CarboplatinChemotherapyThree-dimensional conformal intensity modulated radiation therapyNon-small cell lung cancerAdverse reactions

First-author's address： Department of Radiotherapy，Liaocheng People's Hospital， Liaocheng 252000， China

doi： 10.3969/j.issn.1674-4985.2025.22.017

非小细胞肺癌是一种常见的肺癌类型，危害极大，高效的治疗方案不仅能延长患者的生存期，同时也能提高患者的生活质量。（剩余6466字）