人工智能辅助下多模态超声联合TRAb及VEGF检测对甲状腺结节的精准诊断及临床价值评估

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中图分类号R581 文献标识码A 文章编号2096-7721（2025）11-1860-06

Precise diagnosis and clinical value assessment of thyroid nodules using AI-assisted multimodal ultrasound combined with TRAb and VEGF detection

ZHENGWeiwei， ZHOU Yuwei，LI Huifang，WANG Yang，BAI Lijie （DepartmentofUltrasound，TangshanPeople'sHospital，Tangshan O63OO1，China）

AbstractObjective：ToinvestigatetheprecisediagnosisandclincalvalueofAI-asistedmultimodalultrasoundcombinedwith thyrotropinreceptorantibody（TRAb）andvascularendothelialgrowthfactor（VEGF）detectioninthyroidnodules.Methods：19patints withthyroidnoduleaditedtoTangshanPeople’sHospitalfromJanuary23toSeptember2O24wereenrolld.A-aistedmultiodal ultrasound [conventional AI ultrasound + color Doppler flow imaging （CDFI） + real-time shear wave elastography （SWE） + contrastenhancedultrasond（CEUS）aserford，withostoperativeathologicalrsultssthegoldsadad.Tepatintsereddedt thebenigngroup（n=82）andthemalignant（n=47）group.SerumlevelsofTRAbandVEGFweremeasured，andutrasoundandserum indicators werecomparedbetweenthetwo groups.Thediagnosticvalueof AI-asistedmultimodalultrasoundcombined withserum markers wasanalyzed.Results：ThecombineddetectionofAI-asistedmultimodalutrasoundwithTRAbandVEGFachievedacomplete compliance rate of 98.45% （127/129）with pathological results.Itssensitivity，specificity，positive predictivevalue （PPV），and negative predictive value （NPV） in diagnosing thyroid nodules weresignificantly higher than those of TRAb or VEGFalone （ P <0.05）. Based on pathological results，the diagnostic efficacy （AUC， 95% CI） of TRAb，VEGF，AI-assisted multimodal ultrasound，and their combination were（0.89，）.）.）d）ly with AZ=0.5 1 （P<0.05） .Conclusion： In the diagnosis of benign and malignant thyroid nodules，integrating AI-asisted multimodal ultrasoundfeatureswithserumTRAbandVEGFlevelscansignificantlyimprovedagnosticaccuracyhichhascertainliicalvalue. KeyWordsThyroidNodule;ArtificialIntelligence;MultimodalUltrasound;ThyrotropinReceptorAntibody;VascularEndotelial GrowthFactor;ClinicalValue

甲状腺结节指甲状腺细胞发生异常增殖，进而在甲状腺组织内形成的异常团块结构，是常见的内分泌系统疾病，多发于女性，且发病率随年龄增长而增加[1]。（剩余8606字）