酸性成纤维细胞生长因子在拟南芥中生物合成及透皮递送研究进展

中图分类号 Q812 文献标志码A 文章编号 1007-7731（2026）07-0101-05

DOI号 10.16377/j.cnki.issn1007-7731.2026.07.025

Research progress on biosynthesis and transdermal delivery of acidic fibroblast growth factorin Arabidopsisthaliana

Song Chengyang1Huang Xulong1Wang Junchao²Li Rongrong1Xu Nuo1 （ 1 College of Life and Environmental Science， Wenzhou University，Wenzhou 325o35， China; ²School of Pharmacy Sciences，Wenzhou Medical University，Wenzhou 325035， China）

AbstractThisarticlereviewed thestructural characteristics，skincareeffcts，and strategies for molecular agricultural expressionof acidic fibroblast growth factor（aFGF）.Thefunctional domains of aFGFcanbedivided into the heparin-binding region，receptor-binding region and nuclear translocation region.In the fieldof skin care，aFGF has multiple biological functions such as promotingangiogenesis，accelerating skin injury repair，inhibiting scar formation and delaying skinaging.Currently，aFGF has been expressed in various expressonsystems including Escherichiacoli， Pichia pastoris，insect cels，mammaliancellsand plants，each with itsownadvantages and disadvantages.Theuseof molecular agriculture to expresscytokines such as aFGF has significant advantages such as being free of endotoxins，no pathogencontamination，and low production costs.Peptides that can penetrate cels，such as transdermal peptide1 （TD1），can asist in the penetration of biological macromolecules through the skin barrer.Byfusing aFGF with cellpenetrating peptidesand constructingarecombinant protein，the transdermal eficiency of aFGFcan be significantly enhanced.Arabidopsis thaliana hasa high genetic transformation eficiencyanda short growth cycle，making itan effctive expression system for preparing fusion proteins. Using Arabidopsis thaliana as the expression system to prepare thefusion protein can provide an efective way to develop plant-based skin care ingredients containing aFGF.This articleexplores the feasibilityofthestrategyofusing theTDP1-aFGFfusion protein，which combines theexpresionofArabidopsis thaliana with the cell-penetrating peptide TDP1 of the TD1 mutant type.This provides a reference for enhancing the transdermal ability of aFGFand expanding the application of molecular agriculture.

Keywordsacidic fibroblast growth factor; skin care; molecular agriculture; Arabidopsis thaliana

酸性成纤维细胞生长因子（Acidicfibroblastgrowthfactor，aFGF），是成纤维细胞生长因子家族的关键成员之一。（剩余10530字）