吡格列酮对脓毒症急性肝损伤患者肝功能 及炎症氧化应激的影响

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文献标识码：A

中图分类号： R631+.2 文章编号：1006-1959（2025）23-0113-05

DOI：10.3969/j.issn.1006-1959.2025.23.023

EffectofPioglitazoneonLiverFunctionand Inflammatory Oxidative Stress inSepsisPatientswith AcuteLiver Injury

YUANXiaochun，LUKai，CHENLinxiang，CUIHenghao，XUChenchen，PANChunxia （IntensiveCare Unit，Dafeng People'sHospital/Dafeng HospitalAfiliatedto Xinglin Collegeof Nantong University， Yancheng ，Jiangsu，China）

Abstract：Oeeitesfiecaoaisissstel injury.MethodsAtotalof9OsepsispatientswithcuteliverijuryoerediagosdadtreatedinourospitalfroOctober19tOctober 2024wereseletedsteesearhbectseyeredividedintocontrolgoupndbserationgroupyandomumbertablemetodith45 patientsnachpTtolsadioealtdeiaditolii oftheotrolul functionandcalseeoeadreOFsodedeeaciosa betwen the two groups.Results The total effective rate of treatment in the observation group（91.11 % ）was higher than that in the control group （ 80.00% 0 P<0.05 ）.Theserumtotalbilubi （Til）spatateanotrasferase（Aandalaninanotrasferase（Linthetwogoupsreloer than those before treatment，and those in the observation group were lower than those in the control group（ P<0.05） .Themalondialdehyde（MDA） in thetwogroupshatatforettperoidduase（Odase（CAegroatfoed theMDAntheobservationgroupaslowerthanthatintheontrolgroupandtheSODandCATwerehigherthantoseinthecotrolgoup（ P< （20 0.05）.TheAPACHEIsoredSOFsoreoftetooupserelowerthantoseeforetreamntndtoseoftheseatiogrouelower than those of the control group（ P<0.05） .There was no significant diference in the incidence of adverse reactions between the observation group （11.11 % ）and the control group （8.89% ） P>0.05） .Conclusion Pioglitazone treatment can improve the clinical efcacy of sepsis patientswith acute liverijuysisdt‘ no significant adverse reactions and has relatively good application value.

eyWords：Pioglitazone;Sepsis;Acuteliver injury;Liver function; Inflammatory oxidative stress

脓毒症（sepsis）急性肝损伤发生机制复杂多变，普遍认为与微循环障碍、炎症风暴及代谢紊乱等环节相关。（剩余6054字）