氨基甲酸乙酯麻醉小鼠不同时期脑组织ATP酶活性的变化

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中图分类号：R114 文献标识码：A 文章编号：1006-1959（2025）23-0082-04

DOI：10.3969/j.issn.1006-1959.2025.23.015

Changes ofATPaseActivityin Brain Tisues of Ethyl Carbonate-anesthetized MiceatDifferent Periods

SUN Xiaojing

（SchoolofBasic MedicalSciences，Xuzhou Medical University，Xuzhou 221OO4，Jiangsu，China）

Abstract：OectiveTpreliiailyepoehafboatenducedesthsiabetetingasectivityiftn regionsduringvariousstagesofaesthsiaMethodsKunmingmiceererandomlydividedintofivegroupsbasedondyight（8atsegoup）： control group，induction group，anesthesia group，recovery phase I group and recovery phase I group.The control group received an intraperitoneal injectionof saline，while the other four groupsreceived an intraperitoneal injection of ethyl carbonate（ 1000mg/kg ）.Brain tissues were collected once the mice reached the corresponding state.Na+ K+. -ATPase， Mg2+. -ATPase，and Ca ι2+. -ATPase activities were measured in the cortex，hippocampus， brainstem，and thalamus.Results Compared to the control group，Na+- ⋅K∗ -ATPase， Mg2+ -ATPaseand Ca ！2+ -ATPase activities inall brain regions were decreasedtovaryingdegresduringtheinductionphase，withthemossignificantreductionobservedduringtheanesthesiaphase（ P<0.05） .Na+- ⋅K+. 1 ATPase， Mg2+. -ATPase and Ca2+. -ATPase activities began to recover inboth recovery phaseIandrecovery phaseII.Byrecovery phase I，ATPase activities inall brain regions returned to normal levels（ P>0.05） ，except for Mg2+. -ATPase and Ca2+. -ATPase activities in the cortex.Conclusion The anesthetic effect of ethyl carbonate may be associated with the suppression of ATPase activity.

Keywords：Ethylcarbonate;Anesthesia;ATPase

氨基甲酸乙酯又名乌拉坦，是一种长效麻醉剂，外科麻醉深度可持续4～6h，作用温和持久，对呼吸与循环无明显的抑制，具有骨骼肌松弛的作用[2]。（剩余6865字）