基于网络药理学分析肠道微生物代谢物改善结直肠癌奥沙利铂耐药的作用

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中图分类号：R735.3文献标识码：A

DOI：10.3969/j.issn.1006-1959.2025.23.001 文章编号：1006-1959（2025）23-0001-07

Effectof Intestinal Microbial Metabolites onImproving Oxaliplatin Resistance in Colorectal Cancer Based on Network Pharmacology

HANGXin1，ZHENGQingyong2，XUJianguo²，TIANJinhui²，XUCaihua²，ZHOUYongjia²，CUIYating²，LIUiping 1，2 （1.School ofPharmacy，Gansu Health Vocational College，Lanzhou 73Oooo，Gansu，China;

2.Evidence-BasedMedicineCenter，cholofBasic MedicalSiences，LanzhouUniversityLanzhou73oo，Gansu，Cina）

Abstract：OjetiTsudtotetialhaoftestialobalmeablioprovgaliaiOAsistailotal canceryekcdladeabid referenceforimprovingOXAresistanceofcolorectalcancerbasedonintestinalmicrorganisms.MethodsThegutMGene，PubChem， SwissTargetPreoECadndoeatanaseaedetesall metabolitsdasistailoalcotoeecosucd analyzedbyCyosapeCyoNCAandMCODEplugins.Geneontolog（GOfunctioalerichentandKyotoEncclopediaofGensandGeos （KEGG）enrichment analysis were performed by R software，and molecular docking technology wasusedto verify the interaction between key metabolitesandgetsesultsAotalfainargetseresredoutichayplanipotatregatoyoleiteiprotf OXAresistanceioloalcytestialaletabolioh6deegesGcl ericentalysodattgeseiloldinhosetoloolacidcteraldoleulendi stres.KEGGtalsowdageseldddtoerosisllitorialid pathways.Theutcrobiotaetaboliteeytargtetwoksodtatbutyatecetatepropate，rethylaineidesuiiccid indolepropioniccidndcoindloserelatiosiithAT，ndTesultsofoleuladockingshodtatiding energy of 3-indolepropionic acid and vancomycin to key targets was ⩽ -5.0 kcal/mol，indicating that thebindingwas stable.Conclusion Metabolites oftestiad metabolismand immune response to improveOXA resistanceincolorectal cancer.

Keywords：oloaleeabietloOalsae;ekcoo acids;Molecular docking

结直肠癌（colorectalcancer）是全球严重威胁人类健康的重大疾病。（剩余9056字）