替戈拉生联合高剂量阿莫西林二联方案根除治疗幽门螺杆菌的疗效观察

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中图分类号：R573.6 文章编号：1006-1959（2025）23-0097-04

文献标识码：A

DOI：10.3969/j.issn.1006-1959.2025.23.019

Observation on the Efficacy of Tegoprazan and High-dose Amoxicillin DualTherapyforEradicatingHelicobacterPylori

CHENShuping，XU Ming，LIU Yuandong

（DepartmentofGastroenterologyangraoGangxinistricteople'sospital，angrao3Oo，Jangiina）

Abstract：ObeieTploehlicaltfopaaedigillalaiai ofHelicobacterltsroJueteaisitHfecieeduledtdeHti ShangraoGuangiDtrictoplesHspitalreseletedidditobseaiu（4）dotoo（8）y tablemethodTeoeatogoupastreateditZ+oseAOalteradteotroloratedithisutog quadruple therapy.The Hp eradicationrate，symptom score，clinical eficacyandadversereactionswere compared betweenthetwo groups. ResultsTereasnsignificantdiereeinHradicatiorateetwenthebservaongroundtheotrolgroup（nalysis：92%s. 84.81% PP analysis： 88.03% vs. 87.34% ）（ P> 0.05）.The symptomscores（abdominal pain，abdominal distension，belching）ofthetwogroupsaftertreatment were lower than those before treatment （ Pe <0.05），but there were no significant difference between the two groups （ P> 0.05）.There was no significant difference in the effective rate between the observation group and the control group （91.55% vs. 91.14% ）（P>0.05）. The incidence of adverse reactions in the observation group was lower than that in the control group（ 7.75% vs. 15.82% ），thedifferencewas statistically significant（ P<0.05） ： ConclusionTZcombinedwithhigdoseAMOdaltherapycanefectivelyimprovetheclinicalsymptomsofpatientswithHpinfectionts Hp （204 eradicationateandcompreensivefcacyarecomparabletothoseofonventioalquadupleterapynditsowsgooddugfety

Keywords：Helicobacterpylori;Tegoprazan;Amoxicillin

幽门螺杆菌（helicobacterpylori， Hp ）为消化道疾病常见致病菌之一，可定植于人体胃部，损伤胃上皮细胞，引发细胞增殖异常及炎症等不良问题，若未及时根除，可导致胃炎、消化性溃疡甚至胃癌等严重后果，其根除疗效与患者预后生存息息相关[2]。（剩余5720字）