睡眠障碍患者颈动脉斑块进展的超声动态监测

打开文本图片集

AbstractObjective：Toinvestigate therelationshipbetweensleepdisorders，especiallyObstructive SleepApnea（OSA）andcarotidplaqueprogresionandtoevauateitspotentialimpactofsleepdisordersoatheroslerosis.Methods：Atotalofpatints withsleepdisordersadmitedinthehospitalfromJune2O toJune2O24 wereincludedasthestudyobjects.Theyweredivided into an OSA group（ n=70 ） and a non-OSA group（ n=30 ） according to whether they were OSA patients.All patients underwent polysomnography（PSG）andthecarotid Dopplerultrasound scan beforetheenrollment andhad a6-month folowup.Therelationshipbetwensleedisordersandcarotid plaque progressionwasexploredbyanalyzingsleepmonitoringidicators，suchasapnea index（AHI），lowestbloodoxygenaturation，ndrsultsofcarotidulrasound，incudingplaquemorpholog，ie，tia-dia thickness（IMT），peak systolic velocity（PSV），etc.Results ：The rate of carotid plaque area increase in OSA group（ 60.00% ）was significantly higher than that in non-OSA group 30.00% ） within 6 months and IMT and PSV of the observation group increased significantly. Multivariate regression analysis showed that the IMT increased by 0.15mm2 and PSV increased by 0.18 cm/s for every 1 time/h increase in AHI. For every 1% decrease in the lowest oxygen saturation，the IMT increased by O.1O mm². Conclusion：Sleepdisorders，especiallyOSA，arecloselyassociated withcarotidplaqueprogresion，andtherateofplaqueprogesin OSA patients issignificantlyhigherthanthatinnon-OSApatients.AHIandlowest oxygensaturationareimportantpredictors for carotid plaque progression.

KeywordsSleep disorders; Obstructive sleep apnea; Carotid artery plaque； Ultrasonic dynamic monitoring; Blood oxygen；Apnea index；lowest blood oxygen saturation；Arteriosclerosis

中图分类号：R338.63；R56 文献标识码：A doi：10.3969/j. issn.2095-7130.2025.04.020

睡眠障碍，尤其是阻塞性睡眠呼吸暂停（Ob-structiveSleepApnea，OSA），已被认为与心脑血管疾病的发生密切相关[1]。（剩余3873字）