重复经颅磁刺激联合奥氮平治疗在精神分裂伴失眠患者中的应用及对睡眠质量的影响

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AbstractObjective：Toanalyzetheefectsofrepetitivetranscranialstimulatiocombinedwitholanzapineothesleepqualityof patients withschizophreniaand insomnia.Methods：Atotalof ninetypatientswith schizophreniaandinsomniaadmitted to the FifthPeople'sHospitalof Zibo CityfromJanuary 2O23 to December2024were selectedastheresearchsubjects.Theywererandomly divided into a control group（ n=43 ） and an observation group（ n=47 ）by random number table. The control group was treatedwitholanzapine，whiletheobservationgroupwastreatedwithrepetitivetranscranialmagneticstimulationcombinedwith olanzapine.The Brief PsychiatricRatingScale（BPRS）wasused toevaluatethe degreeofschizophreniainbothgroupsof patients.The Pitsburgh SleepQualityIndex（PSQI）wasusedtoevaluatethechangesinsleepqualitybeforeandafterintervention， andthe incidenceofadversereactions wascomparedbetweenthetwogroups.Results：Aftertheintervention，theBPRSscoreand PSQI scoreoftheobservation groupweresignificantlylowerthan thoseof thecontrol group，andthediference betweenthe two groups was statistically significant（ P<0.05 ）； The incidence of adverse reactions in the observation group was significantly lower than that in the control group and the difference between the two groups showed no statistically significant（ P>0.05 ） . Conclusion：Thecombinationofolanzapineandrepetitivetranscranial magneticstimulationhas significanttherapeutic efectsonpatients with schizophreniaand insomia.Itisnotonlybeneficialforimprovingpatients‘mental symptoms，butalsopromotesthesleep qualtiy back to normal. It is worth promoting and applying in clinical practice.

KeywordsSchizophrenia； Insomnia；Transcranial magnetic stimulation；Repetition； Olanzapine；Mental symptoms；Sleepquality； Adverse event

中图分类号：R749.3;R338.63 文献标识码：A doi：10.3969/j.issn.2095-7130.2025.04.001

精神分裂症属于复杂的慢性精神障碍，全球患病率约为 1% ，其核心症状包括阳性、阴性症状及认知损害。（剩余6044字）