氨氯地平联合艾司唑仑治疗老年高血压伴睡眠障碍患者的疗效研究
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AbstractObjective：Toanalyzetheclinical eficacyofamlodipinecombinedwithestazolam intreatingolderadult patients with hypertensionandcomorbidsleepdisorders.Methods：Atotalof8Oolderadult patientswithhypertensionandsleepdisordersadmitedto heDepartmentof Cardiovascular Medicineat QuanzhouFirst Hospital（FujianProvince）wereenrolled betweenFebruary 2024 and February 2O25.Participants were randomly divided into a control group and an observation group（ n=40 per group） usingarandom numbertable.Thecontrolgroupreceivedamlodipine monotherapy，and theobservation groupreceived estazolam as an add-ontherapytoamlodipine.Before andafter8weeksof treatment，thepatientssystolicanddiastolicbloodpressure were measuredbyelectronicsphygmomanometer，thediferenceof sleepqualitybetweenthetwogroupswasevaluated byPitsurgh Sleep Quality Index（PSQI），andtheimprovement efectofqualityof ifebetweenthe two groups was evaluatedbyGQOL-74，and the therapeutic efects ofthetwogroupswerecompared.Results：After treatment，both groups showed reductionsin systolicand diastolic blood pressure，with the observation group demonstrating significantly lower values than the control group（ P<0.05 ）. Similarly，PtsburghSleepQualityIndex（PSQ）soresdecreasedinothgroupspost-treatment，butweresignificantlylowerin the observation group compared to controls（ P<0.05 ）. Furthermore，Generic Quality of Life Inventory-74（GQOLI-74） scores increased inboth groupsaftertherapy，withtheobservationgroupexhibiting significantlyhigherimprovementsversusthecontrol group（ P<0.05 ）.Conclusion：For older adult patients with hypertension and sleep disorder，the amlodipine-estazolam combinationtherapydemonstratedsgnificanteficcy.Thistherapycanotonlyefectivelyregulatedthebloodpressrelevel，utalsoeffectively optimized the quality of sleep，thereby enhancing the quality of life of patients.
KeywordsOlderadult patients；Hypertension；Sleepdisorders；Amlodipine；Eszolam；Qualityoflife；Clinical eficacySleep quality
中图分类号：R544.1;R338.63 文献标识码：A doi：10.3969/j.issn.2095-7130.2025.04.010
高血压作为老年群体中一种极为普遍的心血管疾病，其潜在危害不容忽视。（剩余5510字）
