氨氯地平联合艾司唑仑治疗老年高血压伴睡眠障碍患者的疗效研究

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AbstractObjective:Toanalyzetheclinical eficacyofamlodipinecombinedwithestazolam intreatingolderadult patients with hypertensionandcomorbidsleepdisorders.Methods:Atotalof8Oolderadult patientswithhypertensionandsleepdisordersadmitedto heDepartmentof Cardiovascular Medicineat QuanzhouFirst Hospital(FujianProvince)wereenrolled betweenFebruary 2024 and February 2O25.Participants were randomly divided into a control group and an observation group( n=40 per group) usingarandom numbertable.Thecontrolgroupreceivedamlodipine monotherapy,and theobservation groupreceived estazolam as an add-ontherapytoamlodipine.Before andafter8weeksof treatment,thepatientssystolicanddiastolicbloodpressure were measuredbyelectronicsphygmomanometer,thediferenceof sleepqualitybetweenthetwogroupswasevaluated byPitsurgh Sleep Quality Index(PSQI),andtheimprovement efectofqualityof ifebetweenthe two groups was evaluatedbyGQOL-74,and the therapeutic efects ofthetwogroupswerecompared.Results:After treatment,both groups showed reductionsin systolicand diastolic blood pressure,with the observation group demonstrating significantly lower values than the control group( P<0.05 ). Similarly,PtsburghSleepQualityIndex(PSQ)soresdecreasedinothgroupspost-treatment,butweresignificantlylowerin the observation group compared to controls( P<0.05 ). Furthermore,Generic Quality of Life Inventory-74(GQOLI-74) scores increased inboth groupsaftertherapy,withtheobservationgroupexhibiting significantlyhigherimprovementsversusthecontrol group( P<0.05 ).Conclusion:For older adult patients with hypertension and sleep disorder,the amlodipine-estazolam combinationtherapydemonstratedsgnificanteficcy.Thistherapycanotonlyefectivelyregulatedthebloodpressrelevel,utalsoeffectively optimized the quality of sleep,thereby enhancing the quality of life of patients.

KeywordsOlderadult patients;Hypertension;Sleepdisorders;Amlodipine;Eszolam;Qualityoflife;Clinical eficacySleep quality

中图分类号:R544.1;R338.63 文献标识码:A doi:10.3969/j.issn.2095-7130.2025.04.010

高血压作为老年群体中一种极为普遍的心血管疾病,其潜在危害不容忽视。(剩余5510字)

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