分析左乙拉西坦对脑卒中后癫痫患者认知功能及睡眠质量的影响

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AbstractObjective：To investigate theefectsof levetiracetamonpatients with post-stroke epilepsy（PSE）.Methods：Atotalof 80 patients with PSEadmitedtotheNeurologyDepartmentof Hospitalbetween January2018 May2O24 were selectedastheresearch subjects.They wereromlydividedintoacontrolgroup anobservation groupusing arom numbertable method，with40 patients ineachgroup.Thecontrol groupreceived sodium valproate，whiletheobservationgroupreceivedlevetiracetam.Observe two groups ofepilepticseizures，ncludingseizure frequency duration.Cognitivefunction wasasessed using the Mini-Mental State Examination（MMSE）， sleepqualitywas evaluated withthe Pitsburgh SleepQuality Index（PSQI）before treatment after6 months.Sleepduration nightime awakenings were documented.Adversereactions-includinganorexia，drowsinesanemia，ndcough-weremonitored.Results：Aftertreatment，the improvementefctofepilepticseizures intheobservationgroupwasbeter thanthatinthecontrol group.The MMSEscore nthe observation groupwassignificantlyhigherthanthatinthecontrolgroup，whilethePSQIscorewassignificantlylower.Thesleep timeinheobservationgroupwassignificantlylonger thanthatinthecontrolgroup，thenumberof nightawakenings was significantlylower.Theincidenceofadversereactionsintheobservatiogroupwas significantlylower than thatinthecontrol group， the differences between the two groups were statistically significant（both P<0.05 ）. Conclusion： Levetiracetam can effectively improve epileptic seizures，enhance cognitive function，improve sleepquality， has good safetyinPSE patients.

KeywordsStroke；Epilepsy；Levetiracetam；Epileptic seizures；Cognitive function；Sleepquality；Adverse reactions 中图分类号：R722. 15+1 ;R338. 63 文献标识码：A doi：10.3969/j. issn.2095 -7130.2025.04.018

脑卒中后患者会出现脑部血液循环障碍，致使脑组织产生缺血、缺氧及水肿情况，严重情况下会导致患者脑组织坏死，从而引起大脑神经元结构和功能改变，诱发癫痫[1]。（剩余4454字）