重症肌无力合并抑郁患者睡眠质量影响因素及干预对策研究

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AbstractObjective：Toanalyzetheinfluencingfactorsofslepqualityandcoresponding intervention strategies inpatientswith myastheniaGravis（MG）comorbid withdepresson.Methods：Atotalof126MG patientswithcomorbiddepresionadmited to theFirstAflatedHospitalofBengbuMedicalUniversity，AnuiProvince，fromSeptember2O2OtoAugust2O24wereselectedas thestudysubjects.Sleepqualitywasasssedusing thePitsburgh SleepQuality Index（PSQI），and patients weredivided into sleep disorder group（ n=92 ）and a non-sleep disorder group（ n=34 ）. Baseline characteristics and laboratory test results were comparedbetweenthetwo groups toanalyzethefactors influencing sleepqualityinMGpatientswithdepression.Results：There were 92 patients with sleep disorders ，accounting for 73.02% . There was a statistically significant difference（ P<0.05 ）in gender，age，durationofMG，concentrationofantiacetylholiereceptorantibody（AChRAb），and HamiltonDepresionRating Scale （HAMD）score between thetwo groups.Theresultsof logistic regressionanalysis showedthat gender，age，durationof MG，AChR Ab concentration，and HAMD score were independent risk factors for sleep disorders in MG patients with depression（ P<0.05 ）.

Conclusion：Patients withMGcombined withdepresionare prone tosleep disorders，and gender，age，MG duration，AChRAb concentrationndHsoreareallftorsatingspqualityTargetedinterventiosaeessarytoimprovesluality in this patient population.

KeywordsMyasthenia Gravis；Depression；Sleequality；Influencing factors；Intervention measures；Anti-Acetylcholine Receptor Antibody

中图分类号：R746.1;R338.63 文献标识码：A doi：10.3969/j. issn.2095-7130.2025.04.014

据统计，中国重症肌无力（MyastheniaGravis，MG）发病率为0.68/10万人年[1]，与年龄、性别呈明显相关性。（剩余4259字）