重症肌无力合并抑郁患者睡眠质量影响因素及干预对策研究

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AbstractObjective:Toanalyzetheinfluencingfactorsofslepqualityandcoresponding intervention strategies inpatientswith myastheniaGravis(MG)comorbid withdepresson.Methods:Atotalof126MG patientswithcomorbiddepresionadmited to theFirstAflatedHospitalofBengbuMedicalUniversity,AnuiProvince,fromSeptember2O2OtoAugust2O24wereselectedas thestudysubjects.Sleepqualitywasasssedusing thePitsburgh SleepQuality Index(PSQI),and patients weredivided into sleep disorder group( n=92 )and a non-sleep disorder group( n=34 ). Baseline characteristics and laboratory test results were comparedbetweenthetwo groups toanalyzethefactors influencing sleepqualityinMGpatientswithdepression.Results:There were 92 patients with sleep disorders ,accounting for 73.02% . There was a statistically significant difference( P<0.05 )in gender,age,durationofMG,concentrationofantiacetylholiereceptorantibody(AChRAb),and HamiltonDepresionRating Scale (HAMD)score between thetwo groups.Theresultsof logistic regressionanalysis showedthat gender,age,durationof MG,AChR Ab concentration,and HAMD score were independent risk factors for sleep disorders in MG patients with depression( P<0.05 ).

Conclusion:Patients withMGcombined withdepresionare prone tosleep disorders,and gender,age,MG duration,AChRAb concentrationndHsoreareallftorsatingspqualityTargetedinterventiosaeessarytoimprovesluality in this patient population.

KeywordsMyasthenia Gravis;Depression;Sleequality;Influencing factors;Intervention measures;Anti-Acetylcholine Receptor Antibody

中图分类号:R746.1;R338.63 文献标识码:A doi:10.3969/j. issn.2095-7130.2025.04.014

据统计,中国重症肌无力(MyastheniaGravis,MG)发病率为0.68/10万人年[1],与年龄、性别呈明显相关性。(剩余4259字)

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