面部皮肤缺损修复改性水凝胶皮瓣材料特性及应用

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中图分类号：TQ431.3 文献标志码：A 文章编号：1001-5922（2025）05-0085-05

Abstract：For the repair treatment of facial skin defects ，methacryloylated gelatin hydrogels were prepared with gelatinand methacrylic anhydride，and then nano-zno modification was caried out.Then，combined with 3D printing technology，a hydrogelflap material was prepared，and its properties were explored.Theresults showedthat the preferred nano-zno solution was 12% and the mass concentration of nano-zno was 50mg/L ，and the hydrogel flap material could be light-cured within 1min ，with good rapid gelation performance，swelling ratio of more than 1000% ，the average diameter of the inhibition zone reaching 0.6mm ，and good cell activity in vitro.The hydrogel flap material preparedunder optimalconditions hadagood efect in the clinical application offacial skin defect repair，with an excellent wound healing rate of 91. 30% ，a healing time of （ 15.36±2.58 ） days，and an improvement in postoperative scar hyperplasia and postoperative satisfaction of 97.83% . In conclusion，this hydrogel flap material can provide a certain data basis for the development of facial skin defect repair treatment.

Key words ：methacryloyl；gelatin ；nano-zno ；hydrogel flap material；antibacterial circle

由于长期紫外线照射、意外伤害或各种疾病的影响，人们的面部皮肤受到损伤。（剩余7244字）