信迪利单抗联合顺铂与吉西他滨对晚期非小细胞肺癌患者客观缓解率、生活质量及无进展生存期的影响

打开文本图片集

中图分类号：R734 文献标识码：A

DOI：10.3969/j.issn.1006-1959.2025.24.033 文章编号：1006-1959（2025）24-0162-04

Effects of Sintilimab Combined with Cisplatin and Gemcitabine on Objective Remisson Rate，Quality of Life and Progresson-free Survival in Patients with Advanced Non-small CellLung Cancer

HONGDaozhongl，HU Tingting² （1.DepartmentofOncology，LepingTianhuHospital，Leping3333Oo，Jiangxi，China; 2.DepartmentofRespiratory，Leping People'sHospital，Leping3333Oo，Jiangxi，China）

Abstract：ObeTvestitefntilomdisplatidciaetisiatealifd progressio-fresualiinsidvadallellungcer（CCtosixtatientsivacdCod andtreatedinourospialfoJetAril3eseedseseaectsredvdtseatioots） andcontrolgroupOpatients）yadoumbertablemetodeotoloupsraedwitsplatidgmcitabindeatio groupwascombndithsintliabontheasisofteontrolgroup.Theetiveremissonateumormarkerlvelualityofifeun functionideefaldcfecoseoadosui rate of the observation group （36.67 % ）washigher than that of the control group （23.33 % ） Pe <0.05）.After treatment，carcinoembryonicantigen （CEA） andcarbohydrate antigen125（CA125）inthetwo groups werelower than those before treatment，GQOLI-74score，CD3 ⋅+ and CD4+were higher than thosebeforetreatment，andCEAandCA125intheobservationgroupwerelowerthantoseinthecontrolgroup，GQOLI-74score，CD 3+ and CD4+ were higher than those in the control group （ P< 0.05）.After15 months of follow-up，the average progression-free survival of the observation group was longer than that of the control group（ P <0.05）.There was no significant difference in the incidence of nausea and vomiting，loss of appetite， leukopenia，bone marrowsuppressonand liverfunction injury between theobservation group and thecontrol group（ P>0.05 .Conclusion Sintilimab combinedwithisplatindgemcitabineasgoodectinthetreatentofdvacedCLC，ichcaniprovethectiversioate reduceteleeiir increase the incidence of adverse reactions.

Keywords：ab;Cispti;ab;dadallellneOeispse;rogioial

晚期非小细胞肺癌（non-small cell lungcancer，NSCLC）是指临床分期ⅢB～IV期，或不可手术的复发患者，临床多以全身治疗为主、局部治疗为辅及姑息支持并重为主要治疗原则，即在控制肿瘤的同时，积极处理癌痛、呼吸困难等症状，以优先保障患者生活质量。（剩余5910字）