多胺代谢相关预后风险评分模型在结肠癌中的构建和验证

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中图分类号： R735.3+5 文章编号：1006-1959（2025）24-0010-06

文献标识码：A

DOI：10.3969/j.issn.1006-1959.2025.24.002

Construction and Validation of Polyamine Metabolism-Related Prognostic Risk Score Model in Colon Cancer

ZHANG Cheng，MI Xun，YEYuting

（DepartmentofMedical Technology，NanjingVocationalHealthCollege，Nanjing21Oooo，Jiangsu，China）

Abstract：ObectieTsstematicallvauateteproosticvalueflyanemetabisrelatedesinolonncendtoostct corespodingsiselsts from514clinicalsamplesintheTCGA-CADcohortwerererieedanddowloadedviatheXenaplatfoPolyainemetabolisrelatedgenes weresearchedusingteeneCardsdtabasendferetiallyssasefoedusingteliaRpackageProgosticelatedgeere furthersrediealsdOdodse wasconstructedeostcueofhsoeasauateduigplaeierrvialsendOrsall sensitiintisousaedugRpasulsAtlof49meabeladse identifiedinteeneCadatabasAfterdieretalalysisdieretalgenefounfchreupreglatedd7re dowregulatedinolocr.Ssidepedntprogosticaueeentidoughiosgorit：RC， GRIN3B，CYP，ndPasedeseisoreoelasostructedndaplaeierures，CndexndOCl showedtatteodeladodprogostcpreditiopefoance.Intusesititalysistintsineloisoupowdiher sensititytoiioosdcsdeulledab prognosticiskscoremodelforCC，providingaewreferencetolforpersoalizedtreatmentandprognosticevaluationinolonancer

KeyWords：Colon cancer;Polyamine metabolism;Prognosis;TCGA

结肠癌（coloncancer）是全球最常见的恶性肿瘤之一，也是导致癌症相关死亡的主要原因[。（剩余7639字）