阿莫西林联合不同铋剂四联方案治疗对海原地区幽门螺杆菌感染患者幽门螺杆菌根除率及不良反应的影响

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中图分类号：R573 文献标识码：A

DOI：10.3969/j.issn.1006-1959.2025.24.027 文章编号：1006-1959（2025）24-0132-05

Effect of Amoxicillin Combined with Different Bismuth Quadruple Regimens onHelicobacterPylori EradicationRateand AdverseReactionsinPatients withHelicobacterPyloriInfectioninHaiyuanArea

MA Linke，MA Shoucheng

（DepartmentofGastroenterologyPeople'sHospitalofNingxiaHuiAutonomousRegion/People'sHospitalofAutonomousRegion Affiliatedto Ningxia Medical University，Yinchuan 75ooO2，Ningxia，China）

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MethodAtotalof5patientsithHifectioninHuanareaadmiedtople'sHospitalofngxiaHuiAutoomousRegiofroFebaryto OctoberO3eedsseatsogttreathtiddtoiot andlevoflxacinoats）othseioilomeprlgesuthctisiceamt groupwastreatediissisdeoflocosraediolilcalcHatte immune function indexes （CD 4+ ，CD4+/CD8 + ，CD8+），inflammatory factorlevels [interleukin-6 （IL-6），tumor necrosis factor -α （TNF- ∇⋅α∝ ），C-reactive protein（CRP）]and incidenceofadversereactions werecompared between the twogroups.ResultsThetotal efectiverate 93.18% ）andHp eradication rate （90.91 % ）of minocycline group were higher than those of levofloxacin group （ 80.65% ， 74.19% ） （P<0.05）.After treatment，CD4 ↓+ and CD4+/CD8 + in the two groups were higher than those before treatment， CD ζ+ was lower than that before treatment，and CD4 ⋅+ and CD4+/CD8 + in the minocycline group were higher than those in the levofloxacin group， CD ζ+ was lower than that in the levofloxacin group （ P<0.05 ）.After treatment，IL6，TNF- α and CRP in the two groups were lower than those before treatment，and IL-6，TNF- ∇⋅αα∝ and CRP in the minocycline group were lower than those in the levofloxacin group（ P<0.05 .Theincidence of adverse reactions in minocycline group （9.09 % ）was lower than that in levofloxacin group （22.58 % ），but thedifference was not statistically significant（ χ2 =3.128，P=O.O77）.Conclusion Amoxicillin combined with esomeprazole magnesium + （20 bismuthpectin + minocyclinequadrupleregimenhasahighereradicationrateofHpinpatientswithHpinfectioninHaiyuanarea.Meanwhile，itcan improvetheciitueatossdetyeabletl

KeyWords：Amoxicilin;ismuth;Quadruplescheme;Helicobacterpylori;Immunefunction;Inflammatoryfactors;Haiuanarea

幽「螺杆菌（Helicobacterpylori， Hp ）是定植于人体胃黏膜的革兰氏阴性杆菌，其感染与慢性胃炎、消化性溃疡、胃癌等消化系统疾病密切相关，全球自然人群感染率超过 50% 。（剩余7659字）