甘露消毒丹加减对溃疡性结肠炎患者中医证候及肠道功能的影响

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中图分类号：R516.1文献标识码：A

DOI：10.3969/j.issn.1006-1959.2025.24.020 文章编号：1006-1959（2025）24-0100-05

Effect of Modified Ganlu Xiaodu Dan on TCM Syndromesand Intestinal Function inPatientswithUlcerativeColitis

SHAO Chungen

enterforPreventive Medicine，NanfengCountyHospitalofTraditionalChineseMedicine，Nanfeng3445oo，Jiangxi，Chi

Abstract：ObjectieTbeetectofodiedGanluXiaouDanintereamentoflerativeolitdtoaleits syndromesanditestialfuctioMetodsAtotalof6patintsiuleratiecolisoeredmiedtoouospialfroJunetoJune 2025wereseletedsteresearchectsTeyweredividedintocontrolgoupndbservationgroupyandomumertablemethodith31 patientsneachgoup.eontrolgrouastreatedihoveioalwesteedicindteevatiogoupastreateditoiedGal XiaoduDaotsisofotroloupeicaletsdroeointestialucoalrerfuctio（Mayooeb index）flcd Results The total effectiverateof the observation group was higher than that of the control group （93.55 % vs. 80.65 % 0 P< 0.05）.After treatment，the scoresofdoalpaiauslododboaltesiineatiogouelowranoolou （ P< O.05）.TheMayosoreadGebosdexofthetogouserelowertantoseeforetreamentndtoseofteoseatiogouprelower than those of the control group（ P <0.05）.The number of Escherichia coli in the two groups was less than that before treatment，the number of LactobacillsasgeaterantatforeaetdberofEheccoiieaioouaslsstanatintto group，the number of Lactobacillus was greater than that in the control group（ P<0.05） .The disappearance time of abdominal pain，fever and constipationintbseatiogroupassorertanthatinteontrolgoup（OO）eresniicantdiereeinthidecf adverse reactions between the observation group and the control group （ P> 0.05）.Conclusion Modified Ganlu Xiaodu Dan addition and subtraction in thetreatentofeatieolinducetsdromeofatients，poeteirtestialfuiondintestialoaoe theclinicaltratapaaalsdilloseeo clinical application.

Key Words：Ganlu Xiaodu Dan;Ulcerative colitis;TCM syndrome; Intestinal mucosal barrier function

溃疡性结肠炎（ulcerativecolitis）的发生与遗传易感性、环境触发、免疫异常及肠道菌群失调密切相关，其核心机制是肠道黏膜免疫系统对肠道菌群的过度激活，导致慢性炎症和黏膜破坏，最终诱发该病。（剩余5883字）