1% 醋酸氢化可的松乳膏治疗慢性湿疹的临床效果及对皮肤屏障功能的影响

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中图分类号：R758.23 文献标识码：A文章编号：1006-1959（2025）17-0138-04

Abstract：Objective Toinvestigatetheclinical effectof 1% hydrocortisone acetate cream in the treatment of chronic eczema and its effect on skin baierfunctioodsotalofatitsitocditdteparetofatolisountolessal fromMay2O23toMayO24wereselectedastheresearchojectsTeyweredividedintocontrolgoupndstudygroupbyrandomubertable method，withOpatientsinchgroup.Tecontrolgroupwastreatedwithloratadinetablets，andthestudygroupastreatedwith 1% hydrocortisone acetateeamlta pruritus）coreet mediator levels [tumor necrosis factor- α （TNF-α），interleukin-17 （IL-17），interleukin-23（IL-23）] were compared between the two groups. Results The total effctive rate of treatment in the study group（96.67 % ）was higher than that in the control group（ 73.33% ）（ P- <0.05）.After treatment，teofstosinesdopelertanoeinoopteatetetdotltf stratumcoeregertatoeiotroloupeoutoftastausaterssaslerthatatitotrolodt level ofserum inflammatory mediators was lower than that in the control group（ P<0.05） . Conclusion 1% hydrocortisone acetate cream is effective in thetreatmentofocachoehcalptosftitsporsieucioddelf seruminflammatorymediators.Itisworthy ofclinicalapplication.

Keywords： 1% hydrocortisone acetate cream;Chronic eczema; Skin barrier functior

慢性湿疹（chroniceczema）是临床常见的一种慢性炎症，该病具有病因较复杂、治疗周期较长且易复发的特点，其临床病症表现为皮肤瘙痒、红肿、皸裂，常见于腿部、手足、肛门等处，症状为皮肤干燥、瘙痒难耐，严重时会导致皮肤大面积溃烂。（剩余5352字）