基于网络药理学和分子对接技术探讨通滞埃提勒菲力沙那片治疗便秘的作用机制

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中图分类号：R965 文献标识码：A文章编号：1006-1959（2025）17-0022-06

Abstract：ObectieToalyetemecanismofTogziAitilefeliSanaabletsinthtreatmentofostipatioyetwokaacod moleculardocingtechoMethodseetwokamacollafoatabaseasusedtoeachdreethctieits andtargetsofTgzitilefelianatabletsndteenCarsdOatabasreedtoenndmmareostiatiead targets.MetasapesedtoaleteGOfunctiondKEGGpathaeicetofthcoeargesDisoerySudoofaeasudtlot theteactioofoleulaingulsalofctieoposdtsofgelib werbadds andESR1.Atotalof5257GOesnd251EGGsigalingpathwaserebtainedichweremainlycedinTFndHF-sialing pathways.Theresultsofmoleculardockingshowedthatthebindingenergyofcorecomponentsandkeytargetswaslow.ConclusionTongzi Aitilefeili Shana tabletscan treat constipation through multi-component，multi-targetand multi-channel.

KeyWords：Networkpharmacology;Moleculardocking;Tongzhi AitilefeiliShana tablets;Constipation

便秘（constipation）属于消化系统常见疾病，是肠道疾病发展的早期症状阶段，我国成年人慢性便秘患病率为 10.9% ，且人群便秘患病率逐年升高[1。（剩余5598字）