伊布替尼对多发性骨髓瘤细胞microRNA-21的影响及其机制研究

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关键词：miR-21;多发性骨髓瘤；伊布替尼;NF-kB;STAT3中图分类号：R965 文献标识码：A文章编号：1006-1959（2025）17-0082-06

DOI：10.3969/j.issn.1006-1959.2025.17.012

Effectof IbrutinibonmicroRNA-21inMultipleMyeloma CellsanditsMechanism

MAJingl2，LINLi’，WANGJinhan³，LIQian14，ZHAOHui5，LIUQiang³，ZHAO Zhigang²，WANGYafei14

DepartmentofHematologyandBloodandarowansplantationanjinCncerHospitalportHospitaanjinO08a; 2.DepartmentofOncology，FirstCentral ClinicalCollge，TianjinMedical University，Tianjin3Oo192，China; 3.Instituteof Radiation Medicine，Chinese Academy of Medical Sciences，Tianjin 3Oo192，China; 4.DepartmentofHematopathology，TianjinMedicalUniversityCancerInstitute&Hospital，TianjinOo6o，China; 5.School of Biotechnologyand Food Science，Tianjin Universityof Commerce，Tianjin3Oo134，China）

Abstract：OectiTetethoftbbifutsseinase）xpressoelfds posibleetptalsisflatifaetofetsaa timePCR（RPC）wasusoeteteexpressoleveofR.Mssuedtoetectheofrutionhetivif cell.WestetigasueetofutibooolatifFdpoteindUt diferentugosexpssiU6l bothU266adLP-1cellsowddowtheprliferatioofMMcell，hileding-21mmicstMcellsibidheproliferaf cels.ThatefllhedieofocepetaWite treatment time and the increase of drug concentration，the protein expressions of p -IkBαandp-p65gradually decreased，whileplOO，p52，IkBα and p65showedosignificantchagesPSTAT（TySer）dereasedwiththeicreaseofdugconcentrationadtheprologationofctioieand STAT3didnotchangesignfctlCoclusionrutibcaneducetendingofbrutibtotetrasiptioninitiatiositeofm-by reducing the activity of phosphorylated NF- ∇⋅kB and phosphorylated STAT3，thus reducing the expression of miR-21 and inhibiting the proliferation of MM cells.

Keywords：miR-21;Multiplemyeloma; Ibrutinib;NF-kB;STAT3

多发性骨髓瘤（multiplemyeloma，MM）为一种以恶性浆细胞克隆增殖为特征的血液系统恶性肿瘤，临床上以贫血、高钙血症、肾功能损害及溶骨性骨破坏为主要表现，约占血液系统恶性肿瘤的10%[1，2] 。（剩余9969字）