MTHFD2基因对人肺腺癌预后的影响

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关键词：亚甲基四氢叶酸脱氢酶2;肺腺癌；细胞增殖相关途径；免疫微环境中图分类号：R734.2 文献标识码：A

DOI：10.3969/j.issn.1006-1959.2025.17.001 文章编号：1006-1959（2025）17-0001-12

Effect of MTHFD2 Gene on the Prognosis of Human Lung Adenocarcinoma

ZHU Yiyang

（Stomatologyspialoolfoatoloyjngesitholfdci，Zjngcalcalse forOralDiseases，KeyLaboratoryofOralBiomedicalResearchof ZhejiangProvince，CancerCenterof Zhejiang University Enginering Research CenterofOralBiomaterialsandDevicesof ZhejiangProvince，Hangzhou31ooo，Zhejiang，China） Abstract：ObectieTevaatetatioipetwetexpressofetlenetetradrofolatergeasedlung adenocarcinoUAD）.etsfoatioofeeresiosledExdGabsesndhl expressionofMDgeneasnalyedKaplanMeierploterasusedtoaalyetelinicalsignificanceofMHeneexpresioite prognosisofpatientswithLUAD.DESeq2Rwasusedtocompare MTHFD2geneexpresiondata（HTseqcount）（riticalvalue=50 1% ）toidentify difrentialyxpresednes（DEGs）.PearsonorelatoaalyssasperfodonNAndothRAuingCGAdatadG andKEGGpathwayenrichmentanalysiswasperfoedon3OOgenesmostpositivelycorelatedwithMFD2.Accordingtothemediangene expresionlevelfHigndlowvels，eUADaplesintCGdtabaseeredividedintotwgroupsndteelf celinfiratismpdIdongepleetalsEedtveleftio Spearmancoelaoalysedteeoelatioeeepesolvedifiaigelbe ResultsMesexpressdinetyfosdiUADteepressoofisssgtin normaltisuesUlcessolssodatexpssledi stage，patholalaoueoigdinaaaedoal showedthatMFDgeneexpresionasanindependentriskfactorfectingtheprogosisofatientswithLUADGeneontologfuction enrichmentaalssdatosiiveleaediellpolfraoeaedndxpressevelf genewasalsoelatedtoeiboecoeviotCocusioexpresfeispdictorofoois inpatients withLUAD，which canbe used asa potential indicator for the diagnosis ofLUAD.

Keywords：Metyleeetraofolatedenase;ungdenoario;Cellprolifeatioeatdpats;ueoiot

肺癌（lungcancer）是世界上癌症相关发病率和死亡率最高的疾病之一，严重威胁着人类的生命和健康。（剩余10677字）