Indian血型系统基因CD44在脑胶质瘤中的临床意义

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中图分类号：R735.7 文献标识码：A文章编号：1006-1959（2025）17-0013-09

DOI：10.3969/j.issn.1006-1959.2025.17.002

Clinical Significance of the Indian Blood Group System Gene CD44 in Glioma

HE Limei

（DepartmentofBloodTransfusion，TongchuanDistrictPeople'sHospital，Dazhou 5Ooo，Sichuan，Chna）

Abstract：ObjetieTinvestgteteprogosticvalueofteIndianblodgoupsstemgeneCD4iliomasanditsoleinmuhapy MethodsTheCGAGGAGE6GSE43378ndGE412cortsreedtvestigateteexpresionlevelgostcac prognosticvalueadiicalsigificanceofCD44inoas.TeCGAcohortasusedtoconstructprogostcodelforoasbsedoD44 expressionddtdll werescrenedforeneontoloGOndKyotoEncylodiaofGnesandGenoes（KEGG）enricentanalysisImmuneifitrationasalyed forthecoelatiof44witreyfiueifiatigcellsdiuepontsMulilacerunoaporssedto analysetheroleofD4iniuoteapResultseexpresioofD4inoissusssigfantlhigerthanhatioalban tisuestpadiopall specificsurvigrlfspl tssuetypingeladrtufsisdoicd prognosticmodelbasedonCD44expressonhadgoodclinicalpracticablityCD44wasmainlyinvolvedintheegulationofimmunesigaling pathwas，dii ofCD44hadalsposeatetiuotheraandaoorogosisCocusioD44isboallyghlyexpresedinoasdis elevatedexpreidos diagnosis and treatment of gliomas.

Keywords：Glioma;CD44; Immunotherapy;Bioinformatics

神经胶质瘤是大脑中最常见的原发性肿瘤，占中枢神经系统恶性肿瘤的 81% ，它们通常起源于神经胶质细胞或前体细胞，并发展为星形细胞瘤、少突胶质细胞瘤、室管膜瘤或少星形细胞瘤[12]。（剩余13636字）