药厂关键工作间压差控制设计与研究

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摘 要：针对药厂灌装线关键工作间之间存在气压串流干扰，导致其压差梯度波动难以控制的问题，分析灌装线关键工作间设备的暖通系统组成以及风阀及通风系统设计架构，对暖通系统与工艺设备进行综合考虑，通过PLC控制系统使工作间压差可自适应工艺生产模式切换而实现智能控制并在实际项目应用中得到验证。

关键词：灌装线；关键工作间；定风量；变风量；压差梯度；PLC

中图分类号：TH122  文献标志码：B  文章编号：1671-5276（2024）01-0175-05

Design and Research on Pressure Differential Control in Key Workshops of Pharmaceutical Plants

WANG Cenjia1， GUO Tao2， QU Haohui2， LIU Shouchao1， WU Baodong1

（1. Nanjing Fuca Automation Technology Co.， Ltd.， Nanjing 210046， China;

2. The Fourth Construction Co.， Ltd. of China Electronics System Engineering， Shijiazhuang 050081，China）

Abstract：Regarding the difficulty in controlling the fluctuation of room differential pressure gradient due to air pressure serial flow interference between key rooms of the filling line of pharmaceutical factory， this paper analyzes the composition of the HVAC system of the equipment in the key rooms of the filling line and the design architecture of the air valve and ventilation system， and takes the HVAC system and process equipment into account comprehensively. With the PLC control system， the room differential pressure can be adaptive to the process production mode switch to achieve intelligent control， which has been verified in actual project application.

Keywords：filling line; key workshops; CAV; VAV; pressure gradient; PLC

0 引言

自疫情爆发以来，国家开始全面推动生物制药的研发和生产建设，并得到了社会的广泛关注。（剩余3498字）