白杨素防治牙周炎的信号通路机制的研究进展

[Abstract]Periodontitisisanon-communicabledisease.As China transitionsintoanaging culture，periodontitis hasemergedasasignificantoralhealthconcernamong theseniorpopulation.Itis theprimarycauseofedentulisminthegeriatricpopulation.Chrysinemonatesdveseayofogicalaos，compsingntflammatoyndtbactealpopert posessesconsiderablepotentialfortepreventionandtreatmentofpriodontaldiseasebecausetoitssafety，on-toxicitydinimumadversersposesChrsincanpreventandtreatpriodoitisbyiibitingteexpressionofiflamatoryfactorsiatesps sionofnuclearfactor-kB（NF-B）signalingpahway，Janusinase（JAK）/signaltransducerandactivatorofranscripton（TAT） signalingpathway（JAK/STAT），andmitogen-activatedproteinkinase（MAPK）signalingpathways.ThisarticlereviewsadvancementsinesearchegardingthesignaltransductionmechanismofChrysininthepreventionandtreatmentofperiodontitisferingaeference for clinical practice.

[Key words] Chrysin；Periodontitis；Anti-inflammatory effect；Antibacterial effect； Signaling pathway

牙周炎是由微生物、环境和遗传等多种因素导致的慢性炎症性疾病，主要特征是牙龈出血、附着丧失、牙槽骨吸收和深牙周袋[1]。（剩余12664字）