细胞焦亡在狼疮性肾炎中的作用及干预进展

[Abstract]Pyroptosis isaformofcelldeathorchestratd bycysteinylaspartatespecificproteinase （Caspase）andcarriedout throughthecleavageofthecellmembranebygasderminDfollowingstimulationbypathogenicmicroorganismsorendogenousdanger signals，culminatingincellmembraneruptureandthereleaseofinflammatorymediators.Lupusnephitis（L）isaseriousconse quenceofsystemiclupuseryhematosus，haracterizedbytheaccumulationofimmunecomplexesintekidneys，esultingininflamtoryreactionsandcellarinjuryPyroptosiscontrbutestotheestablishmentofLNandmayexpeditetheprogresionofLNandother lupusmanifestations.Inhibitingpyroptosisisanticipatedtoenhance theprognosisofLN.Thisreviewexaminesthefunctionofpoto sisinthepatogesisofLndedaementsinssatedtevetiosiesedngteroeespctiefori ical diagnosis and treatment of LN.

[Keywords] Pyroptosis；Lupusnephritis；Inflammatory factors；Caspases；Gasdermin D

狼疮性肾炎（Lupusnephritis，LN）是系统性红斑狼疮（Systemic lupus erythematosus，SLE）中最为严重且最常见的并发症之一，同时也是导致发病和死亡的主要风险因素，高达 10% 的LN患者会发展为终末期肾病（End stagerenal disease，ESRD）[]。（剩余14285字）