基于基因表达谱的个体化疼痛干预对老年结肠癌患者术后恢复效果的影响

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[Abstract]ObjectiveToexploretheefect of personalized paininterventions basedongene expresion profilesontherecoveryotcomesofelderlypatientsaftercoloncancersurgeryMethodsAtotalof0elderlycoloncancersurgicalpatientsaditte totheFirstAfiliatedHospitalofXijiangMedicalUniversityfromApril2O2toJanuaryO24wereselectedastheresearchsubjects. Theyweredividedintotwo groupsusingtherandomnumbertablemethod，with55cases ineach group.Thecontrol groupreceivedroutinepostoperativepaininterventios，hilethebservationgroupreceivedpersoalizedpaininterventionsbasedongneexprssiopr files.Thetwogoupsrecomparedintesofpostopeatierecoveryidicators，visualanalguesale（VA）scoresofptdifer enttimepoints，andCinseversionoffunctioalsessmentofancerterapyeneal（FAC-G）sores.hotalincidencefpost operativecomplicationswasalsocomparedbetweenthetwogroups.ResultsTeobservationgrouphadshorterfistanalexhausttie， first food intake time，and hospitalization time than the control group （ P<0.05 ）. On postoperative day 1 ， 3 ，and 7，the VAS scores of the observation group were lower than those of the control group（ P<0.05 ）.After7 days of intervention，all scores on theFACT-G scale in the observation group were higher than those in the control group （ P<0.05 ）.The total incidence of postoperative complications in the observation group was lower than that in the control group （ P<0.05 ）.ConclusionPersonalized pain interventions based on geneexpresionprofilescansrtenrecoveryie，educepainlvels，improvequalityoflife，ndlowertheiskofpostoperativecomplications in elderly colon cancer patients.

[Key words] Geneexpression profiles；Personalized pain interventions；Colon cancer；Pain；Quality of life；Complications

结肠癌作为全球范围内发病率和死亡率较高的恶性肿瘤之一，尤其在老年人群中，随着年龄的增长，发病率逐年增加。（剩余8664字）