全身免疫炎症指数、C反应蛋白/白蛋白比值预测老年慢性阻塞性肺疾病急性加重合并I型呼吸衰竭预后价值

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[Abstract]ObjectiveTo investigate the prognostic valueofsystemic immune-inflammation index （SI）and CRP/Albratio inelderly patientswith acute exacerbation of chronic obstructive pulmonary disease（COPD）complicated with type I respiratory failure.MethodsClinicaldataof196elderlypatientswithacuteexacerbationofCOPDcombinedwithtypeIrespiratoryfailureadmitted to Jinzhou CentralHospitalfrom March2O19to March2O24were selected，andthepatients weredividedintodeath group（ n=24 ）and survival group （ n=172 ）according to their prognosis after 28 days.SI and CRP/Alb ratio were calculated.Logistic multivariate analysis of prognostic factors of acute exacerbation of COPD combined with type I respiratory failure in elderly patients.ROC curve analysis of theprognosticvalueofSIIcombinedwithCRP/AlbratioinacuteexacerbationofCOPDcombinedwithtypeIrespiratoryfailure. ResultsThere were statisticallysignificant diferences inacutephysiologyandchronichealth evaluationI（APACHEI）score， white blood cell（WBC）count，lymphocyte（LY）count，SII，Alb，CRP，and CRP/Albratio between the twogroups（ P<0.05） ： logistic multivariateanalysisshowedthatAPACHEIsore，WBC，SII，CRP，ndCRP/Albatiowereallrskfctorsfordathinpatients（ P<0.05 ），whileLYcountand Albwereprotective factorsfordeathinpatients（ P<0.05 ）.ROC curve analysis showed that the AUCof SIland CRP/Albratioinpredictigtheprognosticvalueofpatients was0.862（95%CI：0.78～0.946），thesensitvity was 0.792，and thespecificitywasO.826.ConclusionThecombineddetectionofSandCRP/Albratiohashighvalueandacuracyin predicting the prognosis of elderly patients with acute exacerbation of COPD complicated with type I respiratory failure，and can be used as an important indicator to evaluate the prognosis of patients.

[Key words] Chronic obstructive pulmonary disease；Type I respiratory failure；Systemic immune inflammatory index；Creactive protein；Albumin

慢性阻塞性肺疾病（Chronic obstructive pulmo-narydisease，COPD）是一种慢性炎症性疾病，特征为进行性气流受限，主要由吸烟、空气污染和遗传因素等引起[1-2]。（剩余9050字）