原发性甲状腺功能减退症动物模型的中西医评价和病证吻合分析

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Evaluation of animal models of primary hypothyroidism in Chinese and Western medicine and analysis of the disease-pattern consistency

[Abstract]Primaryhypothyroidismisasystemicdiseasecharacterizedbyreducedmetabolicfunctioninthebody，andits incidencerateisincreasingyearbyyearAtpresent，themainstayofWestemedicaltreatmentisthyroidhrmonereplacement buttherearestll problemssuchasdiffcultyinadjustingindividualdoses，unstabletherapeuticefectsforsomepatients，and potentialsideefectsoflong-termmedicationChinesemedicine （CM）hascertainadvantagesinthepreventionandtreatmentof hypothyroidism.However，theexistinganimalmodelsof primaryhypothyroidismaremostlylimitedtotheconstructionofasingle Westernmedical pathological indicator，lacking dynamic simulationof Chinese medicine patters，andtheevaluationsystemisnot yetperfectThroughareviewandanalysisofthemechanismsunderlyingdiferentmodelingmethodsforhypothyroidism，thisstudy hascalculatedtheconsistencyrateofChineseandWestern medicalindicators involvedinthesemethods，evaluatedtheadvantages anddisadvantagesofachmethodaswellastheirompatibilitywithCMpaterntypes，ndproposeddirectionsforimproventIt aimstoprovideatheoreticalbasisforconstructingamoreclinicallyrelevantcombineddisease-paternhypothyroidismmodelof integratedChineseand Westernmedicine，andtoasistinthemechanismresearchand precisepreventionandtreatmentofprimary hypothyroidism.

[Keywords]primary hypothyroidism；animal model;evaluationcriteria;disease-paterncombinationof Chineseand Western medicine;characteristics of pattern type consistency

甲状腺功能减退症简称“甲减”，是一种因甲状腺激素合成或分泌不足导致机体代谢功能减退的全身性疾病，临床以乏力、畏寒、体质量增加、皮肤干燥及心率减缓等低代谢症状为主要表现。（剩余7431字）