基于“调中复衡”理论论治化疗所致周围神经病变

Treatment of chemotherapy-induced peripheral neuropathy based on the theory of "regulating the middle jiao to restore balance"

ZHANG Boling'，LU Aixiao'，YANG Xiwenl， YE Junchen²， ZHANGLi'na²， GUO Hongbo2* 1.Shanxi UniversityofChineseMedicine，JinzhongShanxi O3o619，China;2.TheFirstHspialofShanxiMedicalUniesity Taiyuan，ShanxiO30oo1，China

[Abstract]Chemotherapy-inducedperipheral neuropathy（CIPN）isagrowingconcern inmodemmedicine，with limited efectivepharmacologicalinterventionscurentlyavailable.CINisfundamentallycharacterizedbydeficiencyofthespleeand kidney，withcolteralvesselobstructionsrvingasitssecondarymanifestatio.Deficiencyofhalthyindexcessofpathogenic factorsinteracthroughoutthediseasecourse，leadingtopersistentbloodstasis.Tisarticleelucidatesthepathologicalevoutionof CIPNthroughtelensofEight-PrincipleaternDieretiation，igightingimbalancsinqiandbloddeficiencynde，yi andyang，aswellasvseraldysfunctio.Dfiencyoftespleenandidneyconstiutesterootcauseof，whilebloodtasis obstructingthecollteralsrepresetsitsorepathologicalmechanism.Intreatment，teoreprincipleouldbetdisipateblood stasisandrestorebalance，egulatingthemiddlejiaotonormalizeascendinganddescendingfunctions，anddisipatingbloodstasis and turbiditytounblock thecolaterals.Thispaperaims toprovideanewperspectivefortheclinical managementof CIPN.

[Keywords]chemotherapy-inducedperipheralneuropathy；regulatingthemidlejiaoandrestoringbalance;dissipating bloodstasistounblockcolaterals;reinforcinghealthyqitostrengthenthebody；regulatingthezang-fuorgans；balancingyin and yang;pattern differentiation by the eight principles

化疗所致周围神经病变（chemotherapy-inducedperipheralneuropathy，CIPN）是常见的化疗不良反应，其发生机制较为复杂，多与化疗药物对周围神经的直接毒性作用相关，某些化疗药物可干扰神经细胞的代谢过程，影响神经纤维的结构和功能完整性，导致神经传导速度减慢、感觉功能异常以及运动功能障碍等。（剩余9389字）