基于“寒毒内伏”病机理论探讨奥沙利铂毒副作用的中医药防治策略

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Managing oxaliplatin-induced toxicities with Chinese medicine based on the "latent cold toxin" theory

ZHA NG Sijia， GUO Yingying， TA NG Xiaolong* SuzhouHospital of Integrated Traditional Chineseand Western Medicine，Suzhou， Jiangsu 215ioo，China

[Abstract]Thispaper expounds theunified pathogenesis ofoxaliplatin-induced toxicitiesbasedonthe ChineseMedicine （CM）theoryof"latentcoldtoxin"andsummarizescorrspondingCMinterventions.Itscomonclinicalmanifestationssuchas peripheralneuropathastrotestialactiosndmyelouppresoesmmarzd，andthpatogensisoftseatio isproposedtobecoldtoxin lyinglatentinthecollteralsandblockingth meridians，coldtoxininvadingthespleenandimpairing thespleenyangandlatentcoldtoxininthemarrowexhaustingprimordialyang，respectively.Therapeuticstrategiesemphasize warmingyangandisipatingcold，supplementingqindirculatingblood，srengtheningthespleenandharmozingtoach， and warming the kidneyandreplenishing essence.Commonlyused formulasinclude HuangqiGuizhi Wuwu Decoction，Buzhong YiqiDecoction，YangheDecoction，andtheirmodified formulas，complementedbyexternalCMtherapiessuchasacupuncture， moxibustion，andwarcompreses.udiesinicatetatteseapproacheshelpallviateoxaliplatiducedtoicitisndiprove patients'toleranceandqualityoflife.Thispaperclarifisthat"latentcoldtoxin"istheorepathogenesisofxaliplatin-induced toxicities，proposesatreatmentstrategycenteredonwarmingyanganddetoxification，andprovidesatheoreticalbasisfor subsequent clinical and experimental research.

[Keywords]latentcoldtoxin；oxaliplatin;toxicities;warmingyanganddetoxification;peripheralneuropathy；gastrointesti nal reactions； myelosuppression

近年来，胃癌、结直肠癌等消化系统肿瘤的发病率持续上升，已成为严重威胁生命健康的主要恶性肿瘤之一。（剩余7790字）