诱导铁死亡：逆转胰腺癌对吉西他滨化疗耐药性的新策略

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Abstract：Pancreaticcanerisahighlymalignanttumorofthedigestivesystem，withasignificantlylowerfive-yearsurvivarate thanothermalignancies.Gemcitabine（GEM）istheprimarychemotherapeuticagentforpancreaticcancer，butitseficacyisoften limitedbychemotherapyresistanceof tumor.Thisarticle elaboratesonthe intrinsiccellar mechanismandnon-cel-autonomous mechanism of GEMresistancein pancreaticcancer and summarizes howto enhance thesensitivityof pancreaticcancercells to GEMbyinducing feroptosisthroughtheregulationofpolyunsaturatedfattacidperoxidation，ironmetabolismcontrol，and antioxidantsystems，inorder toinvestigate theassociationbetweeferoptosisandGEMresistance mechanismsandprovidenew directions for the clinical treatment of pancreatic cancer.

Key Words： Ferroptosis;Pancreatic Neoplasms;Drug Resistance，Neoplasm; Gemcitabine

Researchfunding：GeneralProjectofNationalNaturalScienceFoundationofChina（82172712）；GeneralIncubationProgramof Basic Medical Research of Naval Medical University （2O22MS013）

胰腺癌是一种消化系统恶性肿瘤，具有早期诊断难、治疗成功率低、预后差等特点。（剩余17401字）