胆汁淤积性肝病与门静脉高压

打开文本图片集

Abstract：Cholestaticliverdisease（CLD）isagroupofrarechronicliverdiseases withthecorefeatureofbiliarysystemdamage，and theprogresioofCLDisftencomplicatedbyportalhypertension（PH），whichsignificantlyaffctstheprognosisofpatintsTis articlesystematically elaborates on the pathophysiological relationship between CLD and PH ，with a focus on the core mechanisms suchasbileacidtoxicity，fibrosis-drivenmechanisms，andvascularremodeling，anditalsosummarizestheomprehensive managementstrategybasedonevidence-basedmdicinethatintegrates etiologicalreatmentandPHintervention.Furtherstudiesare neded toanalyzetheCLD-PHmolecularnetwork，developprecisetargeted therapies，andpromotetheaplicationofartificial intelligence indisease stratificationand prognosis prediction，soas to improve the clinical outcomes of patients.

KeyWords：Cholestasis；LiverDiseases；Hypertension，Portal

胆汁淤积性肝病（cholestaticliverdisease，CLD）是一种由胆汁生成、分泌或排泄功能障碍引发的病理综合征，其特征为肝内外胆管系统破坏引发胆汁流动力学异常及毒性胆汁酸蓄积，疾病谱涵盖原发性胆汁性胆管炎（primarybiliarycholangitis，PBC）原发性硬化性胆管炎（primarysclerosingcholangitis，PSC）等自身免疫性胆管病。（剩余14210字）