胆汁淤积性肝病的临床管理

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Abstract：Cholestatic liver disease（CLD）isagroupof hepatobiliary disorders causedbyimpaired bileproduction，secretion， orexcretion.With theapplicationof liquidbiopsy，multi-parameterradiological examination，andgenomicstechnology， significant progresshasbeenmade inthediagnosisand prognosticevaluationofCLD.Atpresent，thetherapeutic principles for CLDmainly focusonaddressing theunderlying causesand managing cholestasis，and commonlyused drugs include ursodeoxycholicacid，S-adenosylmethionine，cholestyramine，fibrates，andobeticholicacid.Basedonthelatestclinical consensus statementsandresearchadvances inCLD，thisarticlesystematicallelaboratesontheclinicalmanagementstrategies for CLD from the aspects of diagnosis，treatment，and prognostic evaluation.

KeyWords：Cholestasis；UrsodeoxycholicAcid;ObeticholicAcid

胆汁淤积的核心病理机制在于各种原因导致的肝内外胆汁生成、分泌或排泄障碍。（剩余13275字）