原发性胆汁性胆管炎个性化诊疗策略

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Abstract：Atpresent，therearestllcertainproblemsinthediagnosisandtreatmentofprimarybiliarycholangitis（PBC），suchas alowrateofearlydiagnosis，imitationsintheselectionoftherapeuticdrugs.ForpatientswithatypicalPBCandanorallevelof alkaline phosphatase， ，age，and sex can be used as important indicators for the diagnosis of PBC.By shortening the cycle for evaluation，“Xi’ancriteria”canfacilitateearlyidentificationofpatientswhohaveasuboptimalresponsetoursodesoxycholicacid afterl-monthtreatmentandalowscliicianstoinitiatescond-linetherapeuticagent.Itprovidessignificantplatforminteclinical evaluationofprognosticinformationBasedontheoptiizationofexistingmodelsforprognosticevaluation，newdynamicmodels should beestablishedbasedonserum indicatorsandliverstfesstofacilitateaccurateprognosticassessmentandactivenewdrug research and development.

Keywords：Primary Biliary Cholangitis；Forecasting；Therapeutics

Researchfunding：NationalNaturalScienceFoundationofChina（8227o551）；ScienceandTechnologyInnovationTeamof Shaanxi Province（2024RS-CXTD-79）

原发性胆汁性胆管炎（primarybiliarycholangitis，PBC）是一种以胆汁淤积和胆管纤维化为特点的自身免疫性肝病，发病机制尚不完全清楚[1-2]。（剩余12417字）