脂蛋白X在胆汁淤积性肝病中的作用机制及临床意义

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Abstract：LipoproteinX（LpX）isanatypicallipoproteinthatabnormallyaccumulatesintheplasmaofpatients withcholestatic liverdisease，anditisalsoamajorpathogenicfactorforhypercholesterolemia.TheformationofLpXiscloselyassociatedwiththe abnormalmetabolismoffreecholesterol，phospholipids，andotherlipidcomponents inbile.LpXcannotbeclearedViathelowdensitylipoproteinreceptorpathwayandismainlymetabolizedbythereticuloendothelial system.Theabnormalaccumulationof LpXiscloselyassociatedwithvariouscomplicationsofcholestaticliverdisease，includingxanthomaandneuropathyAlthough thereisnosignificantcorelationbetweenthehighlevelofLpXandtherisofatherosclerosis，theroleofLpXincholesterol metabolismdisorderscannotbeneglected.DuetothesimilaritiesindensityandcharacteristicsbetweenLpXandlow-ensity lipoproteincholesterol，clinicaltesting mayresult inmisdiagnosisandrelated treatmentriss.Currntstudies mainlyfocusonthe mechanismsofLpXformation，theclinicalsignificanceofLpX，relateddetectionmethods，and potentialtherapeuticstrategies. PlasmaexchangeisconsideredthepreferedtreatmentinthestateofhighLpX，whiletraditionallipid-loweringdrugshavea limitedeffectonLpX.Thisaticleexplores theformationandclearancemechanismsofLpXincholestaticliverdisease，along with itsimpactofcholestaticliverdiseaseandrelateddetectionmethods，inordertoimprovetheunderstandingofthepathophsiology andclinicalsignificanceofLpX，providenewstrategiesforthemanagementofcholestaticliverdiseaseanditscomplicatios，and finally improve the prognosis of patients.

Keywords：Lipoprotein-X；Cholestasis；Hypercholesterolemia

Researchfunding：NationalNaturalScienceFoundationofChina（8236Olo8）；InnovationFundforGraduate Studentsof Kunming Medical Universityin 2024（2024S089）

胆汁淤积性肝病是由于胆汁生成、分泌和排泄障碍，导致胆红素和胆汁酸在肝内积累并反流入血液，从而引起肝胆损伤、代谢失衡和功能紊乱的疾病[1-2]。（剩余17226字）