基于中医阴阳学说探讨胆汁酸/短链脂肪酸代谢紊乱与肝性脑病的关系

打开文本图片集

Abstract：Hepaticencephalopathyisaneuropsychiatricsyndromesecondary tosevere liverdisease.Recent studies haveshown thatthedevelopmentofhepaticencephalopathyisloselyassociatedwithbileacid/shorthainfatyacidmetabolicdisorder.Asthe core theoryoftraditionalChinese medicine，thetheoryofYinandYangprovidesauniqueperspectiveforanalyzingtheassociation betwen bileacids/short-chainfatyacidsandhepatic encephalopathy.Bileacidsfunctionlike Yang，governing thefreflowof Qi andassistinginetabolicprocesses，whileshort-chainfattyacidsbelong toYin，maintaininginteraltabilityandconseation， preservingtheintestinalbarier，ndcombating inflammationandtoxins.Bileacidsandshort-chainfattacidconstraineachothr andareinterdependenttoregulatethedynamicequilibriumofthegut-liver-brainaxis.Onthisbasis，byregulatingthemetabolic imbalanceofbileacidsandshort-chainfatyacids，itisexpectedtorestorethedynamic balanceofYinandYanginpatients with hepatic encephalopathy under the synergistic intervention of traditional Chinese medicine and Western medicine.

KeyWords：HepaticEncephalopathy;YinYang Theory；Bile Acid;FattyAcids

Researchfunding：National Natural ScienceFoundationofChina（82260899）；Guangxi Traditional Chinese Medicineand Zhuang Yao Medicine Interdisciplinary Innovation Team（GZKJ2301）；Guangxi KeyResearch and Development Plan Project （GuikeAB22035076）；Guangxi Research Teamof TCMDiagnosisandTreatmentofDificultandCritical Diseases（2022001） Guangxi Graduate Education InnovationProgram Project （YCBZ2024149，YCSY2025051，YCSY2025050，YCSY2025056）

肝性脑病是指由严重肝功能障碍或门静脉-体循环分流异常而引起的以代谢紊乱为基础的中枢神经系统功能紊乱综合征，临床可表现为行为异常、意识障碍甚至昏迷，严重威胁患者的生存质量[1]。（剩余20665字）