肝脏放射密度与慢性乙型肝炎肝纤维化程度的关联性分析

打开文本图片集

Abstract：ObjectiveToinvestigatetheasociationofliverradiodensitywiththedegreeandprogresionofliverfibrosisin patients with chronic hepatitis B（（CHB）.MethodsAretrospectivecohortstudywasconductedamong14 CHBpatients who were hospitalizedinTheFirstHospitalofLanzhouUniversityfromJanuarytoDecember2O19，andrelatedclinicaldatawerecollected， includinglaboratorytestsandabdominalCT.Themetaboliccharacteristicsoftepatientsreassesed，andliveradiodensitywas measured.Ananalysisof variancewasusedforcomparisonof normallydistributedcontinuous databetween thre groups，andthe

Kruskal-Wallis H rank sum test was used forcomparison ofcontinuous data with skewed distribution between three groups；thechi-square testrtheFisher’sxacttestasuedforomparsonofategorcaldataetweentreegrous.Algistcgresioanalsisasusedto investigatetheifuecinfctorsforthgeeoflverfbosis，andteCoxproportioalazadsregesionodelnalysiswasdto investigatetheinfluencingfactorsfortheprogressionof liverfibrosis inCHB.ResultsAmongthe114patientsenolld，43（ 37.72% ）had no liver cirrhosis，30（ 26.32% ）were suspected of liver cirrhosis，and 41（ 35.96% ）had liver cirrhosis，with a median follow-up time of 538.5（322.75—1 031.50） days.Liver radiodensity on plain scan（odds ratio =0.81， 95% confidence interval ⌊CI⌋ ： 0.68—0.97， P= （204号 0.025），liver radiodensity on contrast-enhanced scan （ OR =0.95，95%CI： 0.90—0.99，P=0.037），and liver volume（OR=0.99， 95%CI 0.98—0.99， P <0.001）were independent influencing factors forthedegreeofliver fibrosis.TheunivariateCoxregresionanalysis showed that the low level of HDL （hazard ratio=2.81，95%CI： 1.04-7.54 ， P =0.041）was associated with the progression of liver fibrosis in CHB patients，andtegefivefosis，veodlieddesitowdigfaociatioihergef fibrosis （all P>0.05 ）.ConclusionIn CHB patients，liverradiodensityisanindependent influencing factorforthe degreeof liverfbrosis， and low HDL has a marked influence on the progression of liver fibrosis.

Key Words：HepatitisB，Chronic;Hepatic Fibrosis；LiverRadiodensity

Researchfunding：NationalNaturalScienceFoundationofChina（236Ol32）；GansuProvinceJointScientificResearchFundProject （23JRA1489，24JRRA911）;LanzhouScienceandTechnologyProgramme（2023-2-76）；MajorScientficResearch ProjectonSience andTechnologyInnovationinGasu Health Sector（GSWSZD2024-11）；Beijing HepatologyFoundation（iGandanF-1082023-RGG002， iGandanF-1082024-RGG130）

慢性乙型肝炎（CHB）作为我国肝病的主要群体，其合并肝脂肪变性（hepaticsteatosis，HS）越来越多见，最新文献报道，我国约有 35% 的CHB患者合并有HS[1]。（剩余10658字）