炎症性肠病合并自身免疫性肝病

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Abstract：The coexistence of inflammatory boweldisease（IBD）andautoimmune liver disease（AILD）hasgained increasing atentioninclinical practice，andthereare significantincreasesintheprevalenceratesofautoimmune hepatis（AIH），priary sclerosing cholangitis（PSC），andAIH-PSCoverlapsyndrome among the patients with IBD.Several pathogenic mechanismsare shared between IBDandAILDs，including geneticsusceptibility，dysregulationofthegut-liveraxis，immune imbalance，and abnormalbileacidmetabolism.TheECCOguidelinesrecommendthatpatientswhoaresuspectedofIBDandreceivenotreatment shouldundergoaseriesof liver function tests，including alanineaminotransferase，alkaline phosphatase，gamma-glutamyl transferase，and totalserum bilirubin，aswellasregularrexaminations during follow-up.WhileIBD-AILDpatients haveunique clinicalfeatures，thereisstillalackofuifieddiagnosisand treatmentguidelinesforthiscomorbidity，andtheselectionof therapeuticgoaloftenentailsacarefulbalancebetweentheintestinaltractandtheliver，requiringinterdisciplinarycolabration andcombined therapiesbasedonpathogenesis.Futureresearchshouldfocusonthedynamicregulatorynetworksof thegut-liver axis to develop innovative intervention strategies that ensure both efficacy and safety.

KeyWords：Autoimmune Diseases;Inflammatory Bowel Disease; Therapeutics

Research funding：Health Research & Special Projects Grant of China（2O1502005）

1背景与流行病学

由遗传、环境、免疫因素等相互作用引起的慢性复发性肠道炎症性疾病[1]，主要包括克罗恩病（crohn disease，CD）和溃疡性结肠炎（ulcerativecolitis，UC）。（剩余15794字）