胰岛素清除在代谢相关脂肪性肝病中的作用

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关键词：代谢相关脂肪性肝病；非酒精性脂肪性肝病；胰岛素清除；癌胚抗原相关细胞黏附分子

Abstract： Withtherapid changes inlifestyle，the prevalenceof nonalcoholicfattyliverdisease（NAFLD）hasbecomeincreasingly severeinChina，andithasbecomeamajorpublichealthconcern.Withadeeperunderstandingof thisdisease，thelatest consensus statement haschanged the namefrom NAFLD to MAFLD，andthisupdated definition transitions froman exclusionbasedapproachtoaninclusiveframework，whichnotonlyimprovesclinicaldiagnosticaccuracy，butalsohighlights thekeyolef metabolicdisordersintheprogresionofNAFLD.Inrecentyears，thein-depthstudiesonthemechanismofcarcinoembryonic antigen-associatedcelladesionmolecule-ediatedinsulinclearancehavehiglightedtheimportanceofinsulincearancenthe development and progresionofNAFLD.Thisarticlereviews theresearchadvances intheroleofinsulinclearance inMAFLD.

KeyWords：MetabolicallAsociatedFattyLiverDisease；Non-alcohlicFattyLiverDiseas；InsulinClearance；Carcinoembryonic Antigen-associated CellAdhesion Molecule1

Researchfunding：ScientificResearchProjectofJiangsu Commissionof Health（Z2O20o3O）；BasicResearch PlanProjectof Suzhou2023（Medical AplicationBasic Research）（SKYD2023O75）；ResearchProjectofGusu HealthTalentand ProgramTalent （GSWS2023062）；ScienceandTechnologyPrograms ProjectofWuzhong District2023（MedicalandHealth Field）（wzyw2023010）;

ScienceandTechnology Development PlanofSuzhou 2O23（Basic Research-Medical Application Basic Research）GuidingProject （SKYD2023244）

非酒精性脂肪性肝病（non-alcoholic fatty liver disease，NAFLD）是一种以肝细胞脂肪过度堆积（肝脏中脂肪含量 55% ）为主要特征的进行性疾病，涵盖非酒精性单纯性脂肪肝、非酒精性脂肪性肝炎、肝纤维化及肝癌等不同阶段[1]。（剩余13401字）