生物钟基因在肝癌发生发展与治疗中的研究进展

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关键词：癌，肝细胞；生物钟；昼夜节律；基因，肿瘤抑制

Abstract：Primarylivercancerisoneof themostcommonmalignanttumorsofthedigestivesystem，anditsmorbidityandmortality ratesareincreasing yearbyyear.Recent studieshaveshown that circadian clockgenedisordersarecloselyasociated with the developmentandprogresiooflivercaner，hichprovidesanwperspectivfotheprevention，iagosistreament，andprogois of livercancer.Inadition，targetingcircadianclockgenesalsoshowsacertainclinicalapplicationpotentialinthetreatmentof cancer.Thisarticlereviewsthelatestresearch advances in theroleofcircadianclock genes in the pathogenesis，prevention， treatment，andprognosisoflivercancer，inordertoprovidenewideasfortheclinicaldiagnosisndtreatmentoflivercancer.

Key Words：Carcinoma，Hepatocellular；Biological Clocks；Circadian Rhythm；Genes，Tumor Suppressor

Researchfunding：ScientificResearchProjectofNational ClinicalResearch BaseofTraditionalChineseMedicineofHenan ProvincialAdministration（2O21JDZYO03）；ConstructionProjectofTraditionalChinese MedicineinHenanProvince（STG-ZYX04- 202133）；HenanProvincialHealthCommsionSpcialProjectofTaditionalChineseMedicineScientificResearch（203Z007）

肝细胞癌（HCC）是全球高发的高致死率恶性肿瘤，其发生发展与肿瘤微环境（tumormicroenvironment，TME）动态演变密切相关。（剩余16896字）