获得性免疫缺陷综合征(AIDS)患者合并肝损伤的危险因素及机制

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Abstract：Withtheadventoftheeraofantiretroviraltherapy，thelifespanofindividualslivingwithhumanimmunodeficiencyvirus （HIV）infectionhasbeenextendedsignificantly，andthereisasignificant increaseintheincidencerateof non-acquired immunodeficiency syndrome（AIDS）-related diseases，among which liver diseaseisoneof the maincausesof non-AIDS-related deaths.ThereisstillarelativelyhighincidencerateofiverinjuryinpatientswithHIVinfection，andtherearevariouscausesof liverinjury.TisarticlereviewsthepossbleriskfactorsforliverinjuryandrelatedmechanismsfromtheaspectsofHVinfection， co-infectionwithhepatitisBvirus/hepatitisCvirusandotherpathogens，drugs，metabolicdysfunction，andintestinalbacterial translocation，in order to provide a reference for the management of individuals with HIV infection.

Key Words：HIV；Acquired ImmunodeficiencySyndrome；ChemicalandDrug InducedLiver Injury；HepatitisViruses；NonalcoholicFattyLiverDisease

Researchfunding：KeyR&D PlanofShandongProvince（2O21SFGC0504）

在抗逆转录病毒治疗（antiretroviral therapy，ART）时代到来之前，人类免疫缺陷病毒（human immunodeficiencyvirus，HIV）感染者主要死于获得性免疫缺陷综合征（acquired immunodeficiency syndrome，AIDS）相关疾病，如机会性感染及肿瘤；而ART的普及使得非AIDS相关死亡率相对升高[1]，且因肝脏疾病入院的人数呈上升趋势[2]。（剩余18788字）