基于玄府理论探讨脑卒中“微生物-肠-脑轴”的中医内涵

DOl：10.13457/j.cnki.jncm.2025.16.028

Exploration on the Traditional Chinese Medicine Connotation of the Microbiota-GutBrain Axis in Stroke Based on Sweat Pore Theory

ZHANGXinyue1，JIANGYizhuo²，YU Wentao²，LUOShan²

1.Zhejiang University，Hangzhou Zhejiang310o58，China；2.HebeiUniversityofChinese Medicine，ShijiazhuangHebei05020

Abstract：Stroke is acommon cerebrovasculardisease characterized by high incidence，disability，and mortality rates.Recentadvancements in the microbiota-gut-brainaxis theory have revealed complex interactions between the gut andthe brain，thus providinganovel approach for stroke treatment.Acording tosweat pore theory，disorderof gut microbiotain strokeis akey pathogenic factorcontributing to the accumulationof dampness，heat，phlegm，and blood stasis.Theintestinalbarierandblood-brainbarrierareconsideredthe microscopicmorphological foundationsof sweat pores.The primary pathogenesisof post-stroke neurological dysfunction and cognitive impairment lies in stagnation and obstructionofsweatpores，which preventsqi-fluidfromfreeflowand deactivationof the vitalactivity.Thetherapeutic strategies focus on opening the sweat pores，dredgingqi-fluid，and activating the vital activity，thus providing a holistic approach for stroke.Explorationon the traditionalChinese medicineconnotation of microbiota-gut-brain axis in strokeunder theguidanceof sweat pore theorynotonly advances the theoretical framework of sweat pores but also inspires innovative clinical interventions of stroke.

Keywords：Stroke；Sweat pore theory；Microbiota-gut-brainaxis；Etiology and pathogenesis；Therapeutic principles and treatments

脑卒中是一种常见的脑血管疾病，具有高发病率、高致残率和高死亡率的特点。（剩余7940字）