基于阳虚化风理论应用暖水燥土方治疗帕金森病非运动症状临床研究

∙ 临床证治 ∙

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[关键词」帕金森病；非运动症状；阳虚化风证；暖水燥土方；多巴丝胖片；脑神经递质；神经营养因子 [中图分类号] 1749.1+6 ［文献标志码］A ［文章编号」0256-7415（2025）16-0013-06 DOI:10.13457/j.cnki.jncm.2025.16.003

Clinical Study on Nuanshui Zaotu Formula for Non-Motor Symptoms of Parkinson's Disease Based on Yang Deficiency Transforming into Wind Theory

LIU Jie，QIN Runsun，WANG Baoliang，XU Xiaoyan

DepartmentofEncephalopathy，TheFirstAfliatedHospitalofHenanUniversityofChineseMedicine，ZhengzouHenan450oCina Abstract：Objective：To observe the clinical efficacy of Nuanshui Zaotu Formula in treating non-motor

symptoms of Parkinson's disease(PD）with yang deficiency transforming into wind syndrome.Methods:A prospective

controled study was conducted on 108PD patients with non-motor symptoms of yang deficiency transforming into wind

syndromeadmitted to Departmentof Encephalopathy，The First Afliated Hospitalof Henan Universityof Chinese

Medicine，from January 2O21 to August 2024.Patients were divided into thecontrol group and the observation group

usingtherandom number table method，with 54 cases each.Finaly，50 cases in control group(4 excluded）and 52 cases in observation group（2 excluded）completed the study.The control group received conventional treatment with Levodopaand Benserazide Hydrochloride Tablets，whilethe observationgroup received aditional Nuanshui Zaotu Formula.After eight weeks of treatment，clinical efcacyand traditional Chinese medicinesyndrome scores were evaluated.The Unified Parkinson's Disease Rating Scale（UPDRS）and Non-Motor Symptoms Scale（NMSS）were used to assess symptom improvement.Neurotransmitter levels [5-hydroxytryptamine （5-HT），dopamine（DA），and norepinephrine（NE)]and neurotrophic factors[nerve growth factor（NGF），glialcelline-derived neurotrophic factor （GDNF），and brain-derived neurotrophic factor（BDNF)] were measured.Incidence of adverse reactions were recorded. Results：After treatment，the total effective rate was 86.54% (45/52） in the observation group and 68.00% (34/50） in the control group，the difference being significant （ P

Keywords: Parkinson's disease；Non-motor symptoms；Yang deficiency transforming into wind syndrome; Nuanshui ZaotuFormula；Levodopaand BenserazideHydrochlorideTablets；Brainneurotransmiters；Neurotrophicfactors

帕金森病(PD)是一种好发于老年人群的神经系统退行性疾病，因多巴胺(DA)神经递质的释放减少和脑黑质多巴胺能神经元丢失所引起，其临床症状主要分为非运动症状和运动症状两大类。（剩余11471字）